The meaning of borderline rejection in kidney transplantation.
Kidney Int
; 98(2): 278-280, 2020 08.
Article
in En
| MEDLINE
| ID: mdl-32709286
ABSTRACT
Borderline T cell-mediated rejection is a diagnostic category of the Banff schema that uses a lower diagnostic threshold. Subclinical borderline T cell-mediated rejection detected by surveillance sampling is not entirely benign. Studies demonstrate increased rates of late rejection, progressive nephron loss, functional impairment, donor-specific antibody formation, and allograft failure. It can be conceptualized as a failure to control the cellular alloimmune response. Mixed results are reported for its treatment, and randomized controlled trials are needed.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Kidney Transplantation
Type of study:
Clinical_trials
Limits:
Humans
Language:
En
Journal:
Kidney Int
Year:
2020
Document type:
Article