Advances in Therapeutic Approaches for Spontaneous Intracerebral Hemorrhage.
Neurotherapeutics
; 17(4): 1757-1767, 2020 10.
Article
in En
| MEDLINE
| ID: mdl-32720246
ABSTRACT
Spontaneous intracerebral hemorrhage (ICH) results in high rates of morbidity and mortality, with intraventricular hemorrhage (IVH) being associated with even worse outcomes. Therapeutic interventions in acute ICH have continued to emerge with focus on arresting hemorrhage expansion, clot volume reduction of both intraventricular and parenchymal hematomas, and targeting perihematomal edema and inflammation. Large randomized controlled trials addressing the effectiveness of rapid blood pressure lowering, hemostatic therapy with platelet transfusion, and other clotting complexes and hematoma volume reduction using minimally invasive techniques have impacted clinical guidelines. We review the recent evolution in the management of acute spontaneous ICH, discussing which interventions have been shown to be safe and which may potentially improve outcomes.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cerebral Hemorrhage
/
Minimally Invasive Surgical Procedures
/
Antihypertensive Agents
Type of study:
Clinical_trials
/
Diagnostic_studies
/
Guideline
Limits:
Humans
Language:
En
Journal:
Neurotherapeutics
Journal subject:
NEUROLOGIA
Year:
2020
Document type:
Article
Affiliation country: