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Short- and long-term outcome of patients with aneurysmal subarachnoid hemorrhage.
Roquer, Jaume; Cuadrado-Godia, Elisa; Guimaraens, Leopoldo; Conesa, Gerardo; Rodríguez-Campello, Ana; Capellades, Jaume; García-Arnillas, María P; Fernández-Candil, Juan L; Avellaneda-Gómez, Carla; Giralt-Steinhauer, Eva; Jiménez-Conde, Jordi; Soriano-Tárraga, Carolina; Villalba-Martínez, Gloria; Vivanco-Hidalgo, Rosa M; Vivas, Elio; Ois, Angel.
Affiliation
  • Roquer J; From Servei de Neurologia (J.R., E.C.-G., A.R.-C., C.A.-G., E.G.-S., J.J.-C., C.S.-T., R.M.V.-H., A.O.), Departament J Merland de Neuroangiografia Terapèutica (L.G., E.V.), Servei de Neurocirurgia (G.C., G.V.-M.), Servei de Neuroradiologia (J.C.), Servei de Medicina Intensiva (M.P.G.-A.), and Servei
  • Cuadrado-Godia E; From Servei de Neurologia (J.R., E.C.-G., A.R.-C., C.A.-G., E.G.-S., J.J.-C., C.S.-T., R.M.V.-H., A.O.), Departament J Merland de Neuroangiografia Terapèutica (L.G., E.V.), Servei de Neurocirurgia (G.C., G.V.-M.), Servei de Neuroradiologia (J.C.), Servei de Medicina Intensiva (M.P.G.-A.), and Servei
  • Guimaraens L; From Servei de Neurologia (J.R., E.C.-G., A.R.-C., C.A.-G., E.G.-S., J.J.-C., C.S.-T., R.M.V.-H., A.O.), Departament J Merland de Neuroangiografia Terapèutica (L.G., E.V.), Servei de Neurocirurgia (G.C., G.V.-M.), Servei de Neuroradiologia (J.C.), Servei de Medicina Intensiva (M.P.G.-A.), and Servei
  • Conesa G; From Servei de Neurologia (J.R., E.C.-G., A.R.-C., C.A.-G., E.G.-S., J.J.-C., C.S.-T., R.M.V.-H., A.O.), Departament J Merland de Neuroangiografia Terapèutica (L.G., E.V.), Servei de Neurocirurgia (G.C., G.V.-M.), Servei de Neuroradiologia (J.C.), Servei de Medicina Intensiva (M.P.G.-A.), and Servei
  • Rodríguez-Campello A; From Servei de Neurologia (J.R., E.C.-G., A.R.-C., C.A.-G., E.G.-S., J.J.-C., C.S.-T., R.M.V.-H., A.O.), Departament J Merland de Neuroangiografia Terapèutica (L.G., E.V.), Servei de Neurocirurgia (G.C., G.V.-M.), Servei de Neuroradiologia (J.C.), Servei de Medicina Intensiva (M.P.G.-A.), and Servei
  • Capellades J; From Servei de Neurologia (J.R., E.C.-G., A.R.-C., C.A.-G., E.G.-S., J.J.-C., C.S.-T., R.M.V.-H., A.O.), Departament J Merland de Neuroangiografia Terapèutica (L.G., E.V.), Servei de Neurocirurgia (G.C., G.V.-M.), Servei de Neuroradiologia (J.C.), Servei de Medicina Intensiva (M.P.G.-A.), and Servei
  • García-Arnillas MP; From Servei de Neurologia (J.R., E.C.-G., A.R.-C., C.A.-G., E.G.-S., J.J.-C., C.S.-T., R.M.V.-H., A.O.), Departament J Merland de Neuroangiografia Terapèutica (L.G., E.V.), Servei de Neurocirurgia (G.C., G.V.-M.), Servei de Neuroradiologia (J.C.), Servei de Medicina Intensiva (M.P.G.-A.), and Servei
  • Fernández-Candil JL; From Servei de Neurologia (J.R., E.C.-G., A.R.-C., C.A.-G., E.G.-S., J.J.-C., C.S.-T., R.M.V.-H., A.O.), Departament J Merland de Neuroangiografia Terapèutica (L.G., E.V.), Servei de Neurocirurgia (G.C., G.V.-M.), Servei de Neuroradiologia (J.C.), Servei de Medicina Intensiva (M.P.G.-A.), and Servei
  • Avellaneda-Gómez C; From Servei de Neurologia (J.R., E.C.-G., A.R.-C., C.A.-G., E.G.-S., J.J.-C., C.S.-T., R.M.V.-H., A.O.), Departament J Merland de Neuroangiografia Terapèutica (L.G., E.V.), Servei de Neurocirurgia (G.C., G.V.-M.), Servei de Neuroradiologia (J.C.), Servei de Medicina Intensiva (M.P.G.-A.), and Servei
  • Giralt-Steinhauer E; From Servei de Neurologia (J.R., E.C.-G., A.R.-C., C.A.-G., E.G.-S., J.J.-C., C.S.-T., R.M.V.-H., A.O.), Departament J Merland de Neuroangiografia Terapèutica (L.G., E.V.), Servei de Neurocirurgia (G.C., G.V.-M.), Servei de Neuroradiologia (J.C.), Servei de Medicina Intensiva (M.P.G.-A.), and Servei
  • Jiménez-Conde J; From Servei de Neurologia (J.R., E.C.-G., A.R.-C., C.A.-G., E.G.-S., J.J.-C., C.S.-T., R.M.V.-H., A.O.), Departament J Merland de Neuroangiografia Terapèutica (L.G., E.V.), Servei de Neurocirurgia (G.C., G.V.-M.), Servei de Neuroradiologia (J.C.), Servei de Medicina Intensiva (M.P.G.-A.), and Servei
  • Soriano-Tárraga C; From Servei de Neurologia (J.R., E.C.-G., A.R.-C., C.A.-G., E.G.-S., J.J.-C., C.S.-T., R.M.V.-H., A.O.), Departament J Merland de Neuroangiografia Terapèutica (L.G., E.V.), Servei de Neurocirurgia (G.C., G.V.-M.), Servei de Neuroradiologia (J.C.), Servei de Medicina Intensiva (M.P.G.-A.), and Servei
  • Villalba-Martínez G; From Servei de Neurologia (J.R., E.C.-G., A.R.-C., C.A.-G., E.G.-S., J.J.-C., C.S.-T., R.M.V.-H., A.O.), Departament J Merland de Neuroangiografia Terapèutica (L.G., E.V.), Servei de Neurocirurgia (G.C., G.V.-M.), Servei de Neuroradiologia (J.C.), Servei de Medicina Intensiva (M.P.G.-A.), and Servei
  • Vivanco-Hidalgo RM; From Servei de Neurologia (J.R., E.C.-G., A.R.-C., C.A.-G., E.G.-S., J.J.-C., C.S.-T., R.M.V.-H., A.O.), Departament J Merland de Neuroangiografia Terapèutica (L.G., E.V.), Servei de Neurocirurgia (G.C., G.V.-M.), Servei de Neuroradiologia (J.C.), Servei de Medicina Intensiva (M.P.G.-A.), and Servei
  • Vivas E; From Servei de Neurologia (J.R., E.C.-G., A.R.-C., C.A.-G., E.G.-S., J.J.-C., C.S.-T., R.M.V.-H., A.O.), Departament J Merland de Neuroangiografia Terapèutica (L.G., E.V.), Servei de Neurocirurgia (G.C., G.V.-M.), Servei de Neuroradiologia (J.C.), Servei de Medicina Intensiva (M.P.G.-A.), and Servei
  • Ois A; From Servei de Neurologia (J.R., E.C.-G., A.R.-C., C.A.-G., E.G.-S., J.J.-C., C.S.-T., R.M.V.-H., A.O.), Departament J Merland de Neuroangiografia Terapèutica (L.G., E.V.), Servei de Neurocirurgia (G.C., G.V.-M.), Servei de Neuroradiologia (J.C.), Servei de Medicina Intensiva (M.P.G.-A.), and Servei
Neurology ; 95(13): e1819-e1829, 2020 09 29.
Article in En | MEDLINE | ID: mdl-32796129
ABSTRACT

OBJECTIVE:

To describe short-term and 5-year rates of mortality and poor outcome in patients with spontaneous aneurysmal subarachnoid hemorrhage (aSAH) who received repair treatment.

METHODS:

In this prospective observational study, mortality and poor outcome (modified Rankin Scale score 3-6) were analyzed in 311 patients with aSAH at 3 months, 1 year, and 5 years follow-up. Sensitivity analysis was performed according to treatment modality. In-hospital and 5-year complications were analyzed.

RESULTS:

Of 476 consecutive patients with spontaneous subarachnoid hemorrhage, 347 patients (72.9%) had aSAH. Of these, 311 (89.6%) were treated (242 endovascular, 69 neurosurgical), with a mean follow-up of 43.4 months (range, 1 to 145). Three-month, 1-year, and 5-year mortality was 18.4%, 22.9%, and 29.0%, and poor outcome was observed in 42.3%, 36.0%, and 36.0%, respectively. Adjusted poor outcome was lower in endovascular than in neurosurgical treatment at 3 months (odds ratio [OR] 0.36 [95% confidence interval [CI] 0.18-0.74]), with an absolute difference of 15.8% (number needed to treat = 6.3), and at 1 year (OR = 0.40 [95% CI 0.20-0.81]), with an absolute difference of 15.9% (number needed to treat = 6.3). Complications did not differ between the 2 procedures. However, mechanical ventilation was less frequent with the endovascular technique (OR 0.67 [95% CI 0.54-0.84]).

CONCLUSIONS:

Patients with aSAH treated according to current guidelines had a short-term mortality of 18.4% and 5-year mortality of 29%. The majority (64.0%) of patients remained alive without disabilities at 5-year follow-up. Patients prioritized to endovascular treatment had better outcomes than those referred to neurosurgery because endovascular coiling was not feasible.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Subarachnoid Hemorrhage / Intracranial Aneurysm / Aneurysm, Ruptured Type of study: Guideline / Observational_studies Limits: Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: Neurology Year: 2020 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Subarachnoid Hemorrhage / Intracranial Aneurysm / Aneurysm, Ruptured Type of study: Guideline / Observational_studies Limits: Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: Neurology Year: 2020 Document type: Article