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HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice.
Hoefflin, Rouven; Harlander, Sabine; Schäfer, Silvia; Metzger, Patrick; Kuo, Fengshen; Schönenberger, Désirée; Adlesic, Mojca; Peighambari, Asin; Seidel, Philipp; Chen, Chia-Yi; Consenza-Contreras, Miguel; Jud, Andreas; Lahrmann, Bernd; Grabe, Niels; Heide, Danijela; Uhl, Franziska M; Chan, Timothy A; Duyster, Justus; Zeiser, Robert; Schell, Christoph; Heikenwalder, Mathias; Schilling, Oliver; Hakimi, A Ari; Boerries, Melanie; Frew, Ian J.
Affiliation
  • Hoefflin R; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Harlander S; Institute of Physiology, University of Zurich, Zurich, Switzerland.
  • Schäfer S; Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.
  • Metzger P; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Kuo F; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.
  • Schönenberger D; Faculty of Biology, University of Freiburg, Freiburg, Germany.
  • Adlesic M; Faculty of Biology, University of Freiburg, Freiburg, Germany.
  • Peighambari A; Institute of Medical Bioinformatics and Systems Medicine, Medical Centre-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Seidel P; Immunogenomics & Precision Oncology Platform (IPOP), Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Chen CY; Institute of Physiology, University of Zurich, Zurich, Switzerland.
  • Consenza-Contreras M; Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.
  • Jud A; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Lahrmann B; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.
  • Grabe N; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Heide D; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.
  • Uhl FM; Faculty of Biology, University of Freiburg, Freiburg, Germany.
  • Chan TA; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Duyster J; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.
  • Zeiser R; Institute for Surgical Pathology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Schell C; Institute for Surgical Pathology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Heikenwalder M; Department of General and Visceral Surgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Schilling O; Hamamatsu Tissue Imaging and Analysis (TIGA) Center, BioQuant, University of Heidelberg, Heidelberg, Germany.
  • Hakimi AA; Hamamatsu Tissue Imaging and Analysis (TIGA) Center, BioQuant, University of Heidelberg, Heidelberg, Germany.
  • Boerries M; Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Frew IJ; Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Nat Commun ; 11(1): 4111, 2020 08 17.
Article in En | MEDLINE | ID: mdl-32807776
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Renal Cell / Basic Helix-Loop-Helix Transcription Factors / Hypoxia-Inducible Factor 1, alpha Subunit / Kidney Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2020 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Renal Cell / Basic Helix-Loop-Helix Transcription Factors / Hypoxia-Inducible Factor 1, alpha Subunit / Kidney Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2020 Document type: Article Affiliation country: Country of publication: