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Cooperating, congenital neutropenia-associated Csf3r and Runx1 mutations activate pro-inflammatory signaling and inhibit myeloid differentiation of mouse HSPCs.
Ritter, Malte; Klimiankou, Maksim; Klimenkova, Olga; Schambach, Axel; Hoffmann, Dirk; Schmidt, Amy; Kanz, Lothar; Link, Daniel C; Welte, Karl; Skokowa, Julia.
Affiliation
  • Ritter M; Division of Translational Oncology, Department of Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital Tübingen, Otfried-Müller-Straße 10, 72076, Tübingen, Germany.
  • Klimiankou M; Division of Translational Oncology, Department of Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital Tübingen, Otfried-Müller-Straße 10, 72076, Tübingen, Germany.
  • Klimenkova O; Division of Translational Oncology, Department of Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital Tübingen, Otfried-Müller-Straße 10, 72076, Tübingen, Germany.
  • Schambach A; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.
  • Hoffmann D; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
  • Schmidt A; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.
  • Kanz L; Division of Oncology, Section of Stem Cell Biology, Washington University Medical School, St. Louis, MO, USA.
  • Link DC; Division of Translational Oncology, Department of Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital Tübingen, Otfried-Müller-Straße 10, 72076, Tübingen, Germany.
  • Welte K; Division of Oncology, Section of Stem Cell Biology, Washington University Medical School, St. Louis, MO, USA.
  • Skokowa J; The University Children's Hospital Tübingen, Tübingen, Germany.
Ann Hematol ; 99(10): 2329-2338, 2020 Oct.
Article in En | MEDLINE | ID: mdl-32821971
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Preleukemia / Hematopoietic Stem Cells / Receptors, Colony-Stimulating Factor / Myeloid Cells / Myelopoiesis / Core Binding Factor Alpha 2 Subunit / Congenital Bone Marrow Failure Syndromes / Neutropenia Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Ann Hematol Journal subject: HEMATOLOGIA Year: 2020 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Preleukemia / Hematopoietic Stem Cells / Receptors, Colony-Stimulating Factor / Myeloid Cells / Myelopoiesis / Core Binding Factor Alpha 2 Subunit / Congenital Bone Marrow Failure Syndromes / Neutropenia Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Ann Hematol Journal subject: HEMATOLOGIA Year: 2020 Document type: Article Affiliation country: Country of publication: