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Antimalarial activity of tetrahydro-ß-carbolines targeting the ATP binding pocket of the Plasmodium falciparum heat shock 90 protein.
Eagon, Scott; Hammill, Jared T; Bach, Jordan; Everson, Nikalet; Sisley, Tyler A; Walls, Michael J; Durham, Sierra; Pillai, Dylan R; Falade, Mofolusho O; Rice, Amy L; Kimball, Joshua J; Lazaro, Horacio; DiBernardo, Celine; Kiplin Guy, R.
Affiliation
  • Eagon S; Department of Chemistry and Biochemistry, California Polytechnic State University, San Luis Obispo, CA 93407, USA. Electronic address: seagon@calpoly.edu.
  • Hammill JT; Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY 40508, USA.
  • Bach J; Department of Chemistry and Biochemistry, California Polytechnic State University, San Luis Obispo, CA 93407, USA.
  • Everson N; Promega Biosciences, 277 Granada Drive, San Luis Obispo, CA 93401, USA.
  • Sisley TA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA.
  • Walls MJ; Department of Public Health, Tauro University, Vallejo, CA 94592, USA.
  • Durham S; Department of Food Science and Technology, University of California Davis, Davis, CA 95616, USA.
  • Pillai DR; Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada.
  • Falade MO; Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY 40508, USA.
  • Rice AL; Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY 40508, USA.
  • Kimball JJ; Promega Biosciences, 277 Granada Drive, San Luis Obispo, CA 93401, USA.
  • Lazaro H; Promega Biosciences, 277 Granada Drive, San Luis Obispo, CA 93401, USA.
  • DiBernardo C; Department of Chemistry and Biochemistry, California Polytechnic State University, San Luis Obispo, CA 93407, USA.
  • Kiplin Guy R; Department of Pharmaceutical Sciences, University of Kentucky, Lexington, KY 40508, USA.
Bioorg Med Chem Lett ; 30(21): 127502, 2020 11 01.
Article in En | MEDLINE | ID: mdl-32822760
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasmodium falciparum / Carbolines / Adenosine Triphosphate / HSP90 Heat-Shock Proteins / Antimalarials Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2020 Document type: Article Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasmodium falciparum / Carbolines / Adenosine Triphosphate / HSP90 Heat-Shock Proteins / Antimalarials Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2020 Document type: Article Country of publication: