Implications of flavonoids as potential modulators of cancer neovascularity.
J Cancer Res Clin Oncol
; 146(12): 3079-3096, 2020 Dec.
Article
in En
| MEDLINE
| ID: mdl-32902794
ABSTRACT
PURPOSE:
The formation of new blood vessels from previous ones, angiogenesis, is critical in tissue repair, expansion or remodeling in physiological processes and in various pathologies including cancer. Despite that, the development of anti-angiogenic drugs has great potential as the treatment of cancer faces many problems such as development of the resistance to treatment or an improperly selected therapy approach. An evaluation of predictive markers in personalized medicine could significantly improve treatment outcomes in many patients.METHODS:
This comprehensive review emphasizes the anticancer potential of flavonoids mediated by their anti-angiogenic efficacy evaluated in current preclinical and clinical cancer research. RESULTS ANDCONCLUSION:
Flavonoids are important groups of phytochemicals present in common diet. Flavonoids show significant anticancer effects. The anti-angiogenic effects of flavonoids are currently a widely discussed topic of preclinical cancer research. Flavonoids are able to regulate the process of tumor angiogenesis through modulation of signaling molecules such as VEGF, MMPs, ILs, HIF or others. However, the evaluation of the anti-angiogenic potential of flavonoids within the clinical studies is not frequently discussed and is still of significant scientific interest.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Flavonoids
/
Angiogenesis Inhibitors
/
Neoplasms
/
Neovascularization, Pathologic
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
J Cancer Res Clin Oncol
Year:
2020
Document type:
Article
Affiliation country: