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Design, synthesis, antitrypanosomal activity, DNA/RNA binding and in vitro ADME profiling of novel imidazoline-substituted 2-arylbenzimidazoles.
Popov, Andrea Bistrovic; Krstulovic, Luka; Kostrun, Sanja; Jelic, Dubravko; Bokulic, Ana; Stojkovic, Marijana Radic; Zonjic, Iva; Taylor, Martin C; Kelly, John M; Bajic, Miroslav; Raic-Malic, Silvana.
Affiliation
  • Popov AB; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulicev Trg 20, HR-10000, Zagreb, Croatia.
  • Krstulovic L; Department of Chemistry and Biochemistry, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, HR-10000, Zagreb, Croatia.
  • Kostrun S; Fidelta Ltd., Prilaz Baruna Filipovica 29, HR-10000, Zagreb, Croatia. Electronic address: Sanja.Kostrun@fidelta.eu.
  • Jelic D; Fidelta Ltd., Prilaz Baruna Filipovica 29, HR-10000, Zagreb, Croatia.
  • Bokulic A; Fidelta Ltd., Prilaz Baruna Filipovica 29, HR-10000, Zagreb, Croatia.
  • Stojkovic MR; Division of Organic Chemistry and Biochemistry, Laboratory for Biomolecular Interactions and Spectroscopy, Ruder Boskovic Institute, Bijenicka 54, HR-10000, Zagreb, Croatia.
  • Zonjic I; Division of Organic Chemistry and Biochemistry, Laboratory for Biomolecular Interactions and Spectroscopy, Ruder Boskovic Institute, Bijenicka 54, HR-10000, Zagreb, Croatia.
  • Taylor MC; Department of Infection Biology, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
  • Kelly JM; Department of Infection Biology, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
  • Bajic M; Department of Chemistry and Biochemistry, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, HR-10000, Zagreb, Croatia.
  • Raic-Malic S; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulicev Trg 20, HR-10000, Zagreb, Croatia. Electronic address: sraic@fkit.hr.
Eur J Med Chem ; 207: 112802, 2020 Dec 01.
Article in En | MEDLINE | ID: mdl-32927230
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trypanosoma / Benzimidazoles / DNA / RNA / Drug Design / Imidazolines Type of study: Prognostic_studies Language: En Journal: Eur J Med Chem Year: 2020 Document type: Article Affiliation country: Country of publication:
Fulltext
Add to My VHL
Print
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trypanosoma / Benzimidazoles / DNA / RNA / Drug Design / Imidazolines Type of study: Prognostic_studies Language: En Journal: Eur J Med Chem Year: 2020 Document type: Article Affiliation country: Country of publication: