No SARS-CoV-2 Neutralization by Intravenous Immunoglobulins Produced From Plasma Collected Before the 2020 Pandemic.
J Infect Dis
; 222(12): 1960-1964, 2020 Nov 13.
Article
in En
| MEDLINE
| ID: mdl-32941626
ABSTRACT
The 2020 SARS-CoV-2 pandemic is caused by a zoonotic coronavirus transmitted to humans, similar to earlier events. Whether the other, seasonally circulating coronaviruses induce cross-reactive, potentially even cross-neutralizing, antibodies to the new species in humans is unclear. The question is particularly relevant for people with immune deficiencies, as their health depends on treatment with immunoglobulin preparations that need to contain neutralizing antibodies against the pathogens in their environment. Testing 54 intravenous immunoglobulin preparations, produced from plasma collected in Europe and the United States, confirmed highly potent neutralization of a seasonal coronavirus; however, no cross-neutralization of the new SARS-CoV-2 was seen.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Immunoglobulins, Intravenous
/
Antibodies, Neutralizing
/
SARS-CoV-2
/
Antibodies, Viral
Limits:
Humans
Country/Region as subject:
America do norte
/
Europa
Language:
En
Journal:
J Infect Dis
Year:
2020
Document type:
Article
Affiliation country: