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Phase I clinical trial repurposing all-trans retinoic acid as a stromal targeting agent for pancreatic cancer.
Kocher, Hemant M; Basu, Bristi; Froeling, Fieke E M; Sarker, Debashis; Slater, Sarah; Carlin, Dominic; deSouza, Nandita M; De Paepe, Katja N; Goulart, Michelle R; Hughes, Christine; Imrali, Ahmet; Roberts, Rhiannon; Pawula, Maria; Houghton, Richard; Lawrence, Cheryl; Yogeswaran, Yathushan; Mousa, Kelly; Coetzee, Carike; Sasieni, Peter; Prendergast, Aaron; Propper, David J.
Affiliation
  • Kocher HM; Centre for Tumour Biology, Barts Cancer Institute-A CRUK Centre of Excellence, Queen Mary University London, London, EC1M 6BQ, UK. h.kocher@qmul.ac.uk.
  • Basu B; Centre for Experimental Cancer Medicine, Barts Cancer Institute-A CRUK Centre of Excellence, Queen Mary University of London, London, EC1M 6BQ, UK. h.kocher@qmul.ac.uk.
  • Froeling FEM; Barts and the London HPB Centre, The Royal London Hospital, Barts Health NHS Trust, Whitechapel, London, E1 1FR, UK. h.kocher@qmul.ac.uk.
  • Sarker D; Barts Pancreas Tissue Bank, Barts Cancer Institute-A CRUK Centre of Excellence, Queen Mary University London, London, EC1M 6BQ, UK. h.kocher@qmul.ac.uk.
  • Slater S; Department of Oncology, University of Cambridge and Cambridge University Hospitals NHS Foundation Trust-Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK.
  • Carlin D; Department of Surgery and Cancer, Imperial College London-Hammersmith Hospital, London, W12 0HS, UK.
  • deSouza NM; Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY, 11724, USA.
  • De Paepe KN; School of Cancer and Pharmaceutical Sciences, King's College London, Guy's Hospital Campus, London, SE1 9RT, UK.
  • Goulart MR; Barts and the London HPB Centre, The Royal London Hospital, Barts Health NHS Trust, Whitechapel, London, E1 1FR, UK.
  • Hughes C; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, SW7 3RP, UK.
  • Imrali A; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, SW7 3RP, UK.
  • Roberts R; Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, SW7 3RP, UK.
  • Pawula M; Centre for Tumour Biology, Barts Cancer Institute-A CRUK Centre of Excellence, Queen Mary University London, London, EC1M 6BQ, UK.
  • Houghton R; Centre for Tumour Biology, Barts Cancer Institute-A CRUK Centre of Excellence, Queen Mary University London, London, EC1M 6BQ, UK.
  • Lawrence C; Barts Pancreas Tissue Bank, Barts Cancer Institute-A CRUK Centre of Excellence, Queen Mary University London, London, EC1M 6BQ, UK.
  • Yogeswaran Y; Barts Pancreas Tissue Bank, Barts Cancer Institute-A CRUK Centre of Excellence, Queen Mary University London, London, EC1M 6BQ, UK.
  • Mousa K; PK/Bioanalytics Core Facility, Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK.
  • Coetzee C; PK/Bioanalytics Core Facility, Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK.
  • Sasieni P; Centre for Experimental Cancer Medicine, Barts Cancer Institute-A CRUK Centre of Excellence, Queen Mary University of London, London, EC1M 6BQ, UK.
  • Prendergast A; Centre for Experimental Cancer Medicine, Barts Cancer Institute-A CRUK Centre of Excellence, Queen Mary University of London, London, EC1M 6BQ, UK.
  • Propper DJ; Centre for Experimental Cancer Medicine, Barts Cancer Institute-A CRUK Centre of Excellence, Queen Mary University of London, London, EC1M 6BQ, UK.
Nat Commun ; 11(1): 4841, 2020 09 24.
Article in En | MEDLINE | ID: mdl-32973176

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Tretinoin / Carcinoma, Pancreatic Ductal Type of study: Clinical_trials Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2020 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Tretinoin / Carcinoma, Pancreatic Ductal Type of study: Clinical_trials Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2020 Document type: Article Affiliation country: Country of publication: