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Lead optimization of 8-(methylamino)-2-oxo-1,2-dihydroquinolines as bacterial type II topoisomerase inhibitors.
Ushiyama, Fumihito; Amada, Hideaki; Mihara, Yasuhiro; Takeuchi, Tomoki; Tanaka-Yamamoto, Nozomi; Mima, Masashi; Kamitani, Masafumi; Wada, Reiko; Tamura, Yunoshin; Endo, Mayumi; Masuko, Aiko; Takata, Iichiro; Hitaka, Kosuke; Sugiyama, Hiroyuki; Ohtake, Norikazu.
Affiliation
  • Ushiyama F; Taisho Pharmaceutical Co., Ltd, 1-403 Yoshino-Cho, Kita-Ku, Saitama 331-9530, Japan. Electronic address: f-ushiyama@taisho.co.jp.
  • Amada H; Taisho Pharmaceutical Co., Ltd, 1-403 Yoshino-Cho, Kita-Ku, Saitama 331-9530, Japan.
  • Mihara Y; Taisho Pharmaceutical Co., Ltd, 1-403 Yoshino-Cho, Kita-Ku, Saitama 331-9530, Japan.
  • Takeuchi T; Taisho Pharmaceutical Co., Ltd, 1-403 Yoshino-Cho, Kita-Ku, Saitama 331-9530, Japan.
  • Tanaka-Yamamoto N; Taisho Pharmaceutical Co., Ltd, 1-403 Yoshino-Cho, Kita-Ku, Saitama 331-9530, Japan.
  • Mima M; Taisho Pharmaceutical Co., Ltd, 1-403 Yoshino-Cho, Kita-Ku, Saitama 331-9530, Japan.
  • Kamitani M; Taisho Pharmaceutical Co., Ltd, 1-403 Yoshino-Cho, Kita-Ku, Saitama 331-9530, Japan.
  • Wada R; Taisho Pharmaceutical Co., Ltd, 1-403 Yoshino-Cho, Kita-Ku, Saitama 331-9530, Japan.
  • Tamura Y; Taisho Pharmaceutical Co., Ltd, 1-403 Yoshino-Cho, Kita-Ku, Saitama 331-9530, Japan.
  • Endo M; Taisho Pharmaceutical Co., Ltd, 1-403 Yoshino-Cho, Kita-Ku, Saitama 331-9530, Japan.
  • Masuko A; Taisho Pharmaceutical Co., Ltd, 1-403 Yoshino-Cho, Kita-Ku, Saitama 331-9530, Japan.
  • Takata I; Taisho Pharmaceutical Co., Ltd, 1-403 Yoshino-Cho, Kita-Ku, Saitama 331-9530, Japan.
  • Hitaka K; Taisho Pharmaceutical Co., Ltd, 1-403 Yoshino-Cho, Kita-Ku, Saitama 331-9530, Japan.
  • Sugiyama H; Taisho Pharmaceutical Co., Ltd, 1-403 Yoshino-Cho, Kita-Ku, Saitama 331-9530, Japan.
  • Ohtake N; Taisho Pharmaceutical Co., Ltd, 1-403 Yoshino-Cho, Kita-Ku, Saitama 331-9530, Japan.
Bioorg Med Chem ; 28(22): 115776, 2020 11 15.
Article in En | MEDLINE | ID: mdl-33032189
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinolines / DNA Topoisomerases, Type II / Topoisomerase II Inhibitors / Anti-Bacterial Agents Limits: Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2020 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinolines / DNA Topoisomerases, Type II / Topoisomerase II Inhibitors / Anti-Bacterial Agents Limits: Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2020 Document type: Article