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A Deep Learning Approach Validates Genetic Risk Factors for Late Toxicity After Prostate Cancer Radiotherapy in a REQUITE Multi-National Cohort.
Massi, Michela Carlotta; Gasperoni, Francesca; Ieva, Francesca; Paganoni, Anna Maria; Zunino, Paolo; Manzoni, Andrea; Franco, Nicola Rares; Veldeman, Liv; Ost, Piet; Fonteyne, Valérie; Talbot, Christopher J; Rattay, Tim; Webb, Adam; Symonds, Paul R; Johnson, Kerstie; Lambrecht, Maarten; Haustermans, Karin; De Meerleer, Gert; de Ruysscher, Dirk; Vanneste, Ben; Van Limbergen, Evert; Choudhury, Ananya; Elliott, Rebecca M; Sperk, Elena; Herskind, Carsten; Veldwijk, Marlon R; Avuzzi, Barbara; Giandini, Tommaso; Valdagni, Riccardo; Cicchetti, Alessandro; Azria, David; Jacquet, Marie-Pierre Farcy; Rosenstein, Barry S; Stock, Richard G; Collado, Kayla; Vega, Ana; Aguado-Barrera, Miguel Elías; Calvo, Patricia; Dunning, Alison M; Fachal, Laura; Kerns, Sarah L; Payne, Debbie; Chang-Claude, Jenny; Seibold, Petra; West, Catharine M L; Rancati, Tiziana.
Affiliation
  • Massi MC; Modelling and Scientific Computing Laboratory, Math Department, Politecnico di Milano, Milan, Italy.
  • Gasperoni F; Center for Analysis, Decisions and Society, Human Technopole, Milan, Italy.
  • Ieva F; Medical Research Council-Biostatistic Unit, University of Cambridge, Cambridge, United Kingdom.
  • Paganoni AM; Modelling and Scientific Computing Laboratory, Math Department, Politecnico di Milano, Milan, Italy.
  • Zunino P; Center for Analysis, Decisions and Society, Human Technopole, Milan, Italy.
  • Manzoni A; CHRP-National Center for Healthcare Research and Pharmacoepidemiology, University of Milano-Bicocca, Milan, Italy.
  • Franco NR; Modelling and Scientific Computing Laboratory, Math Department, Politecnico di Milano, Milan, Italy.
  • Veldeman L; Center for Analysis, Decisions and Society, Human Technopole, Milan, Italy.
  • Ost P; CHRP-National Center for Healthcare Research and Pharmacoepidemiology, University of Milano-Bicocca, Milan, Italy.
  • Fonteyne V; Modelling and Scientific Computing Laboratory, Math Department, Politecnico di Milano, Milan, Italy.
  • Talbot CJ; Modelling and Scientific Computing Laboratory, Math Department, Politecnico di Milano, Milan, Italy.
  • Rattay T; Modelling and Scientific Computing Laboratory, Math Department, Politecnico di Milano, Milan, Italy.
  • Webb A; Department of Human Structure and Repair, Ghent University, Ghent, Belgium.
  • Symonds PR; Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium.
  • Johnson K; Department of Human Structure and Repair, Ghent University, Ghent, Belgium.
  • Lambrecht M; Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium.
  • Haustermans K; Department of Human Structure and Repair, Ghent University, Ghent, Belgium.
  • De Meerleer G; Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium.
  • de Ruysscher D; Leicester Cancer Research Centre, Department of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom.
  • Vanneste B; Leicester Cancer Research Centre, Department of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom.
  • Van Limbergen E; Leicester Cancer Research Centre, Department of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom.
  • Choudhury A; Leicester Cancer Research Centre, Department of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom.
  • Elliott RM; Leicester Cancer Research Centre, Department of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom.
  • Sperk E; Department of Radiation Oncology, University Hospitals Leuven, Leuven, Belgium.
  • Herskind C; Department of Radiation Oncology, University Hospitals Leuven, Leuven, Belgium.
  • Veldwijk MR; Department of Radiation Oncology, University Hospitals Leuven, Leuven, Belgium.
  • Avuzzi B; Maastricht University Medical Center, Maastricht, Netherlands.
  • Giandini T; Department of Radiation Oncology (Maastro), GROW Institute for Oncology and Developmental Biology, Maastricht, Netherlands.
  • Valdagni R; Department of Radiation Oncology (Maastro), GROW Institute for Oncology and Developmental Biology, Maastricht, Netherlands.
  • Cicchetti A; Maastricht University Medical Center, Maastricht, Netherlands.
  • Azria D; Department of Radiation Oncology (Maastro), GROW Institute for Oncology and Developmental Biology, Maastricht, Netherlands.
  • Jacquet MF; Translational Radiobiology Group, Division of Cancer Sciences, Manchester Academic Health Science Centre, Christie Hospital, University of Manchester, Manchester, United Kingdom.
  • Rosenstein BS; Translational Radiobiology Group, Division of Cancer Sciences, Manchester Academic Health Science Centre, Christie Hospital, University of Manchester, Manchester, United Kingdom.
  • Stock RG; Department of Radiation Oncology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Collado K; Department of Radiation Oncology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Vega A; Department of Radiation Oncology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Aguado-Barrera ME; Department of Radiation Oncology 1, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
  • Calvo P; Department of Medical Physics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
  • Dunning AM; Department of Radiation Oncology 1, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
  • Fachal L; Department of Oncology and Haemato-Oncology, University of Milan, Milan, Italy.
  • Kerns SL; Prostate Cancer Program, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
  • Payne D; Prostate Cancer Program, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
  • Chang-Claude J; Department of Radiation Oncology, University Federation of Radiation Oncology, Montpellier Cancer Institute, Univ Montpellier MUSE, Grant INCa_Inserm_DGOS_12553, Inserm U1194, Montpellier, France.
  • Seibold P; Department of Radiation Oncology, University Federation of Radiation Oncology, CHU Caremeau, Nîmes, France.
  • West CML; Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
  • Rancati T; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Front Oncol ; 10: 541281, 2020.
Article in En | MEDLINE | ID: mdl-33178576
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Aspects: Patient_preference Language: En Journal: Front Oncol Year: 2020 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Aspects: Patient_preference Language: En Journal: Front Oncol Year: 2020 Document type: Article Affiliation country: Country of publication: