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Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer's disease mouse model.
Cen, Xufeng; Chen, Yanying; Xu, Xiaoyan; Wu, Ronghai; He, Fusheng; Zhao, Qingwei; Sun, Qiming; Yi, Cong; Wu, Jie; Najafov, Ayaz; Xia, Hongguang.
Affiliation
  • Cen X; Department of Biochemistry & Molecular Medical Center, Zhejiang University School of Medicine, Hangzhou, 310058, China.
  • Chen Y; Department of Biochemistry & Molecular Medical Center, Zhejiang University School of Medicine, Hangzhou, 310058, China.
  • Xu X; Department of Biochemistry & Molecular Medical Center, Zhejiang University School of Medicine, Hangzhou, 310058, China.
  • Wu R; Department of Biochemistry & Molecular Medical Center, Zhejiang University School of Medicine, Hangzhou, 310058, China.
  • He F; School of Pharmaceutical and Materials Engineering & Institute for Advanced Studies, Taizhou University, 1139 Shifu Avenue, Taizhou, 318000, China.
  • Zhao Q; Research Center for Clinical Pharmacy & Key Laboratory for Drug Evaluation and Clinical Research of Zhejiang Province, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
  • Sun Q; Department of Biochemistry & Molecular Medical Center, Zhejiang University School of Medicine, Hangzhou, 310058, China.
  • Yi C; Department of Biochemistry & Molecular Medical Center, Zhejiang University School of Medicine, Hangzhou, 310058, China.
  • Wu J; School of Pharmaceutical and Materials Engineering & Institute for Advanced Studies, Taizhou University, 1139 Shifu Avenue, Taizhou, 318000, China. jie_wu@fudan.edu.cn.
  • Najafov A; Department of Cell Biology, Harvard Medical School, Boston, MA, 02115, USA. ayaz_najafov@hms.harvard.edu.
  • Xia H; Department of Biochemistry & Molecular Medical Center, Zhejiang University School of Medicine, Hangzhou, 310058, China. hongguangxia@zju.edu.cn.
Nat Commun ; 11(1): 5731, 2020 11 12.
Article in En | MEDLINE | ID: mdl-33184293

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alzheimer Disease / Mitophagy / Myeloid Cell Leukemia Sequence 1 Protein Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2020 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alzheimer Disease / Mitophagy / Myeloid Cell Leukemia Sequence 1 Protein Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2020 Document type: Article Affiliation country: Country of publication: