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Pharmacological Inhibition of MMP3 as a Potential Therapeutic Option for COVID-19 Associated Acute Respiratory Distress Syndrome.
Kadry, Rana; Newsome, Andrea Sikora; Somanath, Payaningal R.
Affiliation
  • Kadry R; Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia and Charlie Norwood VA Medical Center, Augusta, GA 30912, United States.
  • Newsome AS; Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia and Charlie Norwood VA Medical Center, Augusta, GA 30912, United States.
  • Somanath PR; Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia and Charlie Norwood VA Medical Center, Augusta, GA 30912, United States.
Infect Disord Drug Targets ; 21(6): e170721187996, 2021.
Article in En | MEDLINE | ID: mdl-33200717
ABSTRACT
The high mortality of coronavirus disease 2019 (COVID-19) patients is due to their progression to cytokine-associated organ injuries, primarily the acute respiratory distress syndrome (ARDS). The uncertainties in the molecular mechanisms leading to the switch from the early virus infection to the advanced stage ARDS is a major gridlock in therapeutic development to reduce mortality. Previous studies in our laboratory have identified matrix metalloprotease-3 (MMP3) as an important mediator of bacterial lipopolysaccharide (LPS)-induced ARDS, particularly in the exudative phase. Our studies have also reported elevated plasma MMP3 activity levels in the ARDS patients and that inhibition of MMP3 can reduce the severity of LPS-induced ARDS in mice. Given these observations, targeting MMP3 could be a potential option to treat COVID-19 patients with ARDS, and measurement of MMP3 activity in the plasma may serve as a biomarker for the early detection of ARDS in COVID-19 patients.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Respiratory Distress Syndrome / COVID-19 Type of study: Risk_factors_studies / Screening_studies Limits: Animals / Humans Language: En Journal: Infect Disord Drug Targets Journal subject: DOENCAS TRANSMISSIVEIS / TERAPIA POR MEDICAMENTOS Year: 2021 Document type: Article Affiliation country:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Respiratory Distress Syndrome / COVID-19 Type of study: Risk_factors_studies / Screening_studies Limits: Animals / Humans Language: En Journal: Infect Disord Drug Targets Journal subject: DOENCAS TRANSMISSIVEIS / TERAPIA POR MEDICAMENTOS Year: 2021 Document type: Article Affiliation country: