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A 3D culture platform enables development of zinc-binding prodrugs for targeted proliferation of ß cells.
Yang, Kisuk; Lee, Miseon; Jones, Peter Anthony; Liu, Sophie S; Zhou, Angela; Xu, Jun; Sreekanth, Vedagopuram; Wu, Jamie L Y; Vo, Lillian; Lee, Eunjee A; Pop, Ramona; Lee, Yuhan; Wagner, Bridget K; Melton, Douglas A; Choudhary, Amit; Karp, Jeffrey M.
Affiliation
  • Yang K; Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Lee M; Center for Nanomedicine, Harvard Stem Cell Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Jones PA; Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA.
  • Liu SS; Proteomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Zhou A; David H. Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02142, USA.
  • Xu J; Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Sreekanth V; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
  • Wu JLY; Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Vo L; Center for Nanomedicine, Harvard Stem Cell Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Lee EA; Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA.
  • Pop R; Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Lee Y; Center for Nanomedicine, Harvard Stem Cell Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Wagner BK; Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Melton DA; Center for Nanomedicine, Harvard Stem Cell Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Choudhary A; Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Karp JM; Center for Nanomedicine, Harvard Stem Cell Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Sci Adv ; 6(47)2020 11.
Article in En | MEDLINE | ID: mdl-33208361
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prodrugs / Diabetes Mellitus, Type 2 Limits: Humans Language: En Journal: Sci Adv Year: 2020 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prodrugs / Diabetes Mellitus, Type 2 Limits: Humans Language: En Journal: Sci Adv Year: 2020 Document type: Article Affiliation country: Country of publication: