Differential induction of type I and III interferon genes in the upper respiratory tract of patients with coronavirus disease 2019 (COVID-19).
Virus Res
; 295: 198283, 2021 04 02.
Article
in En
| MEDLINE
| ID: mdl-33418027
ABSTRACT
The natural course of type I and III interferon (IFN) response in the respiratory tract of COVID-19 patients needs to be better defined. We showed that type I/III IFNs, IFN-regulatory factor 7 (IRF7), and IFN stimulated genes (ISGs), are highly expressed in the oropharyngeal cells of SARS-CoV-2 positive patients compared to healthy controls. Notably, the subgroup of critically-ill patients that required invasive mechanical ventilation had a general decrease in expression of IFN/ISG genes. Heterogeneous patterns of IFN-I/III response in the respiratory tract of COVID-19 patients may be associated to COVID-19 severity.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oropharynx
/
Interferon Type I
/
Interferons
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SARS-CoV-2
/
COVID-19
Limits:
Adult
/
Aged
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Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
Virus Res
Journal subject:
VIROLOGIA
Year:
2021
Document type:
Article