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Seasonal Influence on the Numbers of Gender-Related Orofacial Cleft Conceptions in the Netherlands.
van der Lek, Lisanne M; Pool, Shariselle M W; de Jong, Kim; Vermeij-Keers, Christl; Mouës-Vink, Chantal M.
Affiliation
  • van der Lek LM; Department of Ear, Nose and Throat, 4480Medical Center Leeuwarden, Leeuwarden, the Netherlands.
  • Pool SMW; Department of Plastic Surgery, 10173University Medical Center Utrecht, the Netherlands.
  • de Jong K; Department of Epidemiology, 4480Medical Center Leeuwarden, Leeuwarden, the Netherlands.
  • Vermeij-Keers C; Department of Plastic and Reconstructive Surgery, Erasmus MC, 10173University Medical Center Rotterdam, the Netherlands; Dutch Association for Cleft Palate and Craniofacial Anomalies the Netherlands.
  • Mouës-Vink CM; Department of Plastic Surgery, 4480Medical Center Leeuwarden, Leeuwarden, the Netherlands.
Cleft Palate Craniofac J ; 58(11): 1422-1429, 2021 11.
Article in En | MEDLINE | ID: mdl-33467910
ABSTRACT

BACKGROUND:

In the multifactorial etiology of orofacial clefts (OFCs), environmental factors play an important role. To trace the influence of these factors, the timing of the cell biological mechanisms that occur during embryological development of the primary and secondary palates must be taken into account. That is, the fusion process of the facial and palatal processes, respectively, followed by their differentiation into bone and musculature, which take place during the first trimester of pregnancy. During this period, harmful seasonal influences such as viral infections and vitamin deficiencies could induce OFC in the embryo.

AIMS:

The aim of this study is to find out whether a seasonal conception period with an increased risk of OFC development exists, particularly gender related.

METHODS:

This was a retrospective cross-sectional study on children with OFC born in the Netherlands from 2006 to 2016. Total conception rates of live births in the Netherlands were used as a control group. χ2 tests were performed to analyze monthly and seasonal differences. Males and females, positive and negative family history and subphenotype groups based on fusion and/or differentiation (F- and/or D-) defects, and their timing in embryogenesis were analyzed separately.

RESULTS:

In total, 1653 children with OFC, 1041 males and 612 females, were analyzed. Only males with FD-defects showed a significant seasonal variation with an increase in conceptions during spring, most often in May.

CONCLUSIONS:

Males with FD-defects showed a significant seasonal variation with an increase in conceptions during spring. No other seasonal trends could be demonstrated.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cleft Lip / Cleft Palate Type of study: Observational_studies / Prevalence_studies / Risk_factors_studies Aspects: Determinantes_sociais_saude Limits: Female / Humans / Male / Pregnancy Country/Region as subject: Europa Language: En Journal: Cleft Palate Craniofac J Journal subject: ODONTOLOGIA Year: 2021 Document type: Article Affiliation country:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cleft Lip / Cleft Palate Type of study: Observational_studies / Prevalence_studies / Risk_factors_studies Aspects: Determinantes_sociais_saude Limits: Female / Humans / Male / Pregnancy Country/Region as subject: Europa Language: En Journal: Cleft Palate Craniofac J Journal subject: ODONTOLOGIA Year: 2021 Document type: Article Affiliation country:
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