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Effects of rifampicin on the pharmacokinetics of alflutinib, a selective third-generation EGFR kinase inhibitor, and its metabolite AST5902 in healthy volunteers.
Zhu, Yun-Ting; Zhang, Yi-Fan; Jiang, Jin-Fang; Yang, Yong; Guo, Li-Xia; Bao, Jing-Jing; Zhong, Da-Fang.
Affiliation
  • Zhu YT; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, People's Republic of China.
  • Zhang YF; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, People's Republic of China. yfzhang@simm.ac.cn.
  • Jiang JF; HQ Bioscience Co., LTD, Suzhou, People's Republic of China.
  • Yang Y; HQ Bioscience Co., LTD, Suzhou, People's Republic of China.
  • Guo LX; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, People's Republic of China.
  • Bao JJ; Shanghai Allist Pharmaceuticals Co., Ltd, Shanghai, People's Republic of China.
  • Zhong DF; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai, 201203, People's Republic of China. dfzhong@simm.ac.cn.
Invest New Drugs ; 39(4): 1011-1018, 2021 08.
Article in En | MEDLINE | ID: mdl-33506323
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Pyrimidines / Rifampin / Protein Kinase Inhibitors / Cytochrome P-450 CYP3A Inducers / Indoles Type of study: Prognostic_studies Limits: Adolescent / Adult / Female / Humans / Male / Middle aged Language: En Journal: Invest New Drugs Year: 2021 Document type: Article Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Pyrimidines / Rifampin / Protein Kinase Inhibitors / Cytochrome P-450 CYP3A Inducers / Indoles Type of study: Prognostic_studies Limits: Adolescent / Adult / Female / Humans / Male / Middle aged Language: En Journal: Invest New Drugs Year: 2021 Document type: Article Country of publication: