A case of IVIg responsive paraneoplastic SOX1 peripheral neuropathy in a male with breast carcinoma.
J Neuroimmunol
; 352: 577492, 2021 03 15.
Article
in En
| MEDLINE
| ID: mdl-33508769
ABSTRACT
BACKGROUND AND AIMS:
SOX1 antibodies are generally associated with small cell lung cancer and anti-Hu antibody overlap is common. This case demonstrates isolated anti-SOX1 antibodies with an uncommon tumor type, and relapse of a paraneoplastic syndrome with recurrence of tumor.METHODS:
We describe a case of a 65-year-old male with a paraneoplastic peripheral neuropathy and anti-SOX1 antibody positivity in the context of a prior male breast Grade 2 ductal carcinoma, in remission at the time of the initial neurological presentation.RESULTS:
Treatment response to intravenous immunoglobulin (IVIg) was demonstrated. After period of clinical stability on IVIg in the context of remission of breast carcinoma, the patient experienced a relapse of his neuropathy. This was associated with tumor recurrence and again responded to tumor excision, radiotherapy and IVIg.INTERPRETATION:
Male breast carcinoma has not previously been associated with anti-SOX1 antibody positive paraneoplastic neuropathy.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carcinoma, Ductal, Breast
/
Breast Neoplasms, Male
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Paraneoplastic Polyneuropathy
/
SOXB1 Transcription Factors
Limits:
Aged
/
Humans
/
Male
Language:
En
Journal:
J Neuroimmunol
Year:
2021
Document type:
Article
Affiliation country: