Your browser doesn't support javascript.
loading
Fasting and overfeeding affect the expression of the immunity- or inflammation-related genes in the liver of poultry via endogenous retrovirus.
Liu, Tongjun; Xing, Ya; Fan, Xue; Chen, Zhenzhen; Zhao, Chao; Liu, Long; Zhao, Minmeng; Hu, Xuming; Dong, Biao; Wang, Jian; Cui, Hengmi; Gong, Daoqing; Geng, Tuoyu.
Affiliation
  • Liu T; College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
  • Xing Y; College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
  • Fan X; College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
  • Chen Z; College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
  • Zhao C; College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
  • Liu L; College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
  • Zhao M; College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
  • Hu X; College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
  • Dong B; Department of Animal Science and Technology, Jiangsu Agri-Animal Husbandry Vocational College, Taizhou 225300, China.
  • Wang J; Department of Animal Science and Technology, Jiangsu Agri-Animal Husbandry Vocational College, Taizhou 225300, China.
  • Cui H; College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
  • Gong D; College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
  • Geng T; College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China. Electronic address: tygeng@yzu.edu.cn.
Poult Sci ; 100(2): 973-981, 2021 Feb.
Article in En | MEDLINE | ID: mdl-33518151
ABSTRACT
It is known that nutrition and immunity are connected, but the mechanism is not very clear. Endogenous retroviruses (ERV) account for 8 to 10% of the human and mouse genomes and play an important role in some biological processes of animals. Recent studies indicate that the activation of ERV can affect the expression of the immunity- or inflammation-related genes, and the activities of ERV are subjected to regulation of many factors including nutritional factors. Therefore, we hypothesize that nutritional status can affect the expression of the immunity- or inflammation-related genes via ERV. To verify this hypothesis, the nutritional status of animals was altered by fasting or overfeeding, and the expression of intact ERV (ERVK18P, ERVK25P) and immunity- or inflammation-related genes (DDX41, IFIH1, IFNG, IRF7, STAT3) in the liver was determined by quantitative PCR, followed by overexpressing ERVK25P in goose primary hepatocytes and determining the expression of the immunity- or inflammation-related genes. The data showed that compared with the control group (no fasting), the expression of ERV and the immunity- or inflammation-related genes was increased in the liver of the fasted chickens but decreased in the liver of the fasted geese. Moreover, compared with the control group (routinely fed), the expression of ERV and the immunity- or inflammation-related genes was increased in the liver of the overfed geese. In addition, overexpression of ERVK25P in goose primary hepatocytes can induce the expression of the immunity- or inflammation-related genes. In conclusion, these findings suggest that ERV mediate the effects of fasting and overfeeding on the expression of the immunity- or inflammation-related genes, the mediation varied with poultry species, and ERV and the immunity- or inflammation-related genes may be involved in the development of goose fatty liver. This study provides a potential mechanism for the connection between nutrition and immunity.
Subject(s)
Key words
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Poultry / Hyperphagia / Fasting / Endogenous Retroviruses Limits: Animals Language: En Journal: Poult Sci Year: 2021 Document type: Article Affiliation country:
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Poultry / Hyperphagia / Fasting / Endogenous Retroviruses Limits: Animals Language: En Journal: Poult Sci Year: 2021 Document type: Article Affiliation country: