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Gut microbiota from patients with arteriosclerotic CSVD induces higher IL-17A production in neutrophils via activating RORγt.
Cai, Wei; Chen, Xiaodong; Men, Xuejiao; Ruan, Hengfang; Hu, Mengyan; Liu, Sanxin; Lu, Tingting; Liao, Jinchi; Zhang, Bingjun; Lu, Danli; Huang, Yinong; Fan, Ping; Rao, Junping; Lei, Chunyan; Wang, Jihui; Ma, Xiaomeng; Zhu, Qiang; Li, Lili; Zhu, Xiuyun; Hou, Yujiao; Li, Shu; Dong, Qing; Tian, Qing; Ai, Lulu; Luo, Wenjing; Zuo, Mengyun; Shen, Liping; Xie, Congyan; Song, Hongzhong; Xu, Ganlin; Zheng, Kangdi; Zhang, Zhao; Lu, Yongjun; Qiu, Wei; Chen, Tao; Xiang, Andy Peng; Lu, Zhengqi.
Affiliation
  • Cai W; Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
  • Chen X; Center of Clinical Immunology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
  • Men X; Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou 510080, China.
  • Ruan H; Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
  • Hu M; Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
  • Liu S; Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
  • Lu T; Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
  • Liao J; Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
  • Zhang B; Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
  • Lu D; Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
  • Huang Y; Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
  • Fan P; Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
  • Rao J; Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
  • Lei C; Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
  • Wang J; Department of Neurology, Yuedong Hospital, the Third Affiliated Hospital of Sun Yat-sen University, Meizhou, Guangdong 514011, China.
  • Ma X; South China Institute of Biomedicine, Guangzhou, Guangdong 510535, China.
  • Zhu Q; Department of Psychiatry, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China.
  • Li L; Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
  • Zhu X; Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
  • Hou Y; Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
  • Li S; Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
  • Dong Q; Department of Neurology, Yuedong Hospital, the Third Affiliated Hospital of Sun Yat-sen University, Meizhou, Guangdong 514011, China.
  • Tian Q; Department of Neurology, Yuedong Hospital, the Third Affiliated Hospital of Sun Yat-sen University, Meizhou, Guangdong 514011, China.
  • Ai L; Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
  • Luo W; Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
  • Zuo M; Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
  • Shen L; Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
  • Xie C; Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
  • Song H; Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
  • Xu G; Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
  • Zheng K; Department of Neurology, Yuedong Hospital, the Third Affiliated Hospital of Sun Yat-sen University, Meizhou, Guangdong 514011, China.
  • Zhang Z; South China Institute of Biomedicine, Guangzhou, Guangdong 510535, China.
  • Lu Y; South China Institute of Biomedicine, Guangzhou, Guangdong 510535, China.
  • Qiu W; South China Institute of Biomedicine, Guangzhou, Guangdong 510535, China.
  • Chen T; Run Ze Laboratory for Gastrointestinal Microbiome Study, School of Life Sciences and Biomedical Center of Sun Yat-sen University, Guangzhou, Guangdong 510275, China.
  • Xiang AP; Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
  • Lu Z; South China Institute of Biomedicine, Guangzhou, Guangdong 510535, China.
Sci Adv ; 7(4)2021 01.
Article in En | MEDLINE | ID: mdl-33523954
ABSTRACT
The intestinal microbiota shape the host immune system and influence the outcomes of various neurological disorders. Arteriosclerotic cerebral small vessel disease (aCSVD) is highly prevalent among the elderly with its pathological mechanisms yet is incompletely understood. The current study investigated the ecology of gut microbiota in patients with aCSVD, particularly its impact on the host immune system. We reported that the altered composition of gut microbiota was associated with undesirable disease outcomes and exacerbated inflammaging status. When exposed to the fecal bacterial extracts from a patient with aCSVD, human and mouse neutrophils were activated, and capacity of interleukin-17A (IL-17A) production was increased. Mechanistically, RORγt signaling in neutrophils was activated by aCSVD-associated gut bacterial extracts to up-regulate IL-17A production. Our findings revealed a previously unrecognized implication of the gut-immune-brain axis in aCSVD pathophysiology, with therapeutic implications.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gastrointestinal Microbiome Limits: Aged / Animals / Humans Language: En Journal: Sci Adv Year: 2021 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gastrointestinal Microbiome Limits: Aged / Animals / Humans Language: En Journal: Sci Adv Year: 2021 Document type: Article Affiliation country: