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Discovery of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor: Scaffold hopping approach.
Ledneczki, István; Tapolcsányi, Pál; Gábor, Eszter; Visegrády, András; Vass, Márton; Éles, János; Holm, Patrik; Horváth, Anita; Pocsai, Anikó; Mahó, Sándor; Greiner, István; Krámos, Balázs; Béni, Zoltán; Kóti, János; Káncz, Anna E; Thán, Márta; Kolok, Sándor; Laszy, Judit; Balázs, Ottilia; Bugovits, Gyula; Nagy, József; Vastag, Mónika; Szájli, Ágota; Bozó, Éva; Lévay, György; Lendvai, Balázs; Némethy, Zsolt.
Affiliation
  • Ledneczki I; Department of Chemistry, Gedeon Richter Plc., Budapest, Hungary. Electronic address: ledneczki@richter.hu.
  • Tapolcsányi P; Department of Chemistry, Gedeon Richter Plc., Budapest, Hungary.
  • Gábor E; Department of Chemistry, Gedeon Richter Plc., Budapest, Hungary.
  • Visegrády A; Department of Chemistry, Gedeon Richter Plc., Budapest, Hungary; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
  • Vass M; Department of Chemistry, Gedeon Richter Plc., Budapest, Hungary.
  • Éles J; Department of Chemistry, Gedeon Richter Plc., Budapest, Hungary.
  • Holm P; Orion Pharma, Turku, Finland.
  • Horváth A; Department of Chemistry, Gedeon Richter Plc., Budapest, Hungary.
  • Pocsai A; Department of Chemistry, Gedeon Richter Plc., Budapest, Hungary.
  • Mahó S; Department of Chemistry, Gedeon Richter Plc., Budapest, Hungary.
  • Greiner I; Research Management, Gedeon Richter Plc., Budapest, Hungary.
  • Krámos B; Spectroscopic Research Department, Gedeon Richter Plc., Budapest, Hungary.
  • Béni Z; Spectroscopic Research Department, Gedeon Richter Plc., Budapest, Hungary.
  • Kóti J; Spectroscopic Research Department, Gedeon Richter Plc., Budapest, Hungary.
  • Káncz AE; Department of Chemistry, Gedeon Richter Plc., Budapest, Hungary.
  • Thán M; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
  • Kolok S; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
  • Laszy J; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
  • Balázs O; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
  • Bugovits G; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
  • Nagy J; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
  • Vastag M; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
  • Szájli Á; Department of Chemistry, Gedeon Richter Plc., Budapest, Hungary.
  • Bozó É; Department of Chemistry, Gedeon Richter Plc., Budapest, Hungary.
  • Lévay G; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
  • Lendvai B; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
  • Némethy Z; Pharmacological and Drug Safety Research, Gedeon Richter Plc., Budapest, Hungary.
Eur J Med Chem ; 214: 113189, 2021 Mar 15.
Article in En | MEDLINE | ID: mdl-33540354
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Nicotinic Agonists / Drug Discovery Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Eur J Med Chem Year: 2021 Document type: Article Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Nicotinic Agonists / Drug Discovery Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Eur J Med Chem Year: 2021 Document type: Article Country of publication: