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Torsadogenic Action of Cisapride, dl-Sotalol, Bepridil, and Verapamil Analyzed by the Chronic Atrioventricular Block Cynomolgus Monkeys: Comparison With That Reported in the CiPA In Silico Mechanistic Model.
Goto, Ai; Sakamoto, Kengo; Kambayashi, Ryuichi; Nunoi, Yoshio; Izumi-Nakaseko, Hiroko; Kawai, Shinichi; Takei, Yoshinori; Matsumoto, Akio; Kanda, Yasunari; Sugiyama, Atsushi.
Affiliation
  • Goto A; Department of Pharmacology, Toho University Graduate School of Medicine, Ota-ku, Tokyo 143-8540, Japan.
  • Sakamoto K; Safety Research Center Ina Research Inc., Ina-shi, Nagano 399-4501, Japan.
  • Kambayashi R; Department of Pharmacology, Faculty of Medicine, Toho University, Ota-ku, Tokyo 143-8540, Japan.
  • Nunoi Y; Department of Pharmacology, Faculty of Medicine, Toho University, Ota-ku, Tokyo 143-8540, Japan.
  • Izumi-Nakaseko H; Department of Pharmacology, Toho University Graduate School of Medicine, Ota-ku, Tokyo 143-8540, Japan.
  • Kawai S; Department of Pharmacology, Faculty of Medicine, Toho University, Ota-ku, Tokyo 143-8540, Japan.
  • Takei Y; Department of Inflammation & Pain Control Research, Faculty of Medicine, Toho University, Ota-ku, Tokyo 143-8540, Japan.
  • Matsumoto A; Department of Translational Research & Cellular Therapeutics, Faculty of Medicine, Toho University, Ota-ku, Tokyo 143-8540, Japan.
  • Kanda Y; Department of Aging Pharmacology, Faculty of Medicine, Toho University, Ota-ku, Tokyo 143-8540, Japan.
  • Sugiyama A; Division of Pharmacology, National Institute of Health Sciences, Kawasaki, Kanagawa 210-9501, Japan.
Toxicol Sci ; 181(1): 125-133, 2021 04 27.
Article in En | MEDLINE | ID: mdl-33544870
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Torsades de Pointes / Atrioventricular Block Limits: Animals Language: En Journal: Toxicol Sci Journal subject: TOXICOLOGIA Year: 2021 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Torsades de Pointes / Atrioventricular Block Limits: Animals Language: En Journal: Toxicol Sci Journal subject: TOXICOLOGIA Year: 2021 Document type: Article Affiliation country: Country of publication: