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Off-target binding of an anti-amyloid beta monoclonal antibody to platelet factor 4 causes acute and chronic toxicity in cynomolgus monkeys.
Loberg, Lise I; Chhaya, Meha; Ibraghimov, Alexander; Tarcsa, Edit; Striebinger, Andreas; Popp, Andreas; Huang, Lili; Oellien, Frank; Barghorn, Stefan.
Affiliation
  • Loberg LI; Development Sciences, AbbVie Inc ., North Chicago, IL, USA.
  • Chhaya M; Global Biologics, AbbVie Inc ., Worcester, MA, USA.
  • Ibraghimov A; Preclinical Safety, AbbVie Inc ., Worcester, MA, USA.
  • Tarcsa E; DMPK-BA, AbbVie Inc ., Worcester, MA, USA.
  • Striebinger A; Discovery Biology, AbbVie Deutschland GmbH & Co. KG , Ludwigshafen, Germany.
  • Popp A; Preclinical Safety, AbbVie Deutschland GmbH & Co. KG , Ludwigshafen, Germany.
  • Huang L; Global Biologics, AbbVie Inc ., Worcester, MA, USA.
  • Oellien F; Discovery Chemistry, AbbVie Deutschland GmbH & Co. KG , Ludwigshafen, Germany.
  • Barghorn S; Discovery Biology, AbbVie Deutschland GmbH & Co. KG , Ludwigshafen, Germany.
MAbs ; 13(1): 1887628, 2021.
Article in En | MEDLINE | ID: mdl-33596779
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood Platelets / Platelet Factor 4 / Amyloid beta-Peptides / Purpura, Thrombocytopenic, Idiopathic / Alzheimer Vaccines / Antibodies, Monoclonal, Humanized / Immunity, Heterologous Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans / Male Language: En Journal: MAbs Journal subject: ALERGIA E IMUNOLOGIA Year: 2021 Document type: Article Affiliation country: Country of publication:
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood Platelets / Platelet Factor 4 / Amyloid beta-Peptides / Purpura, Thrombocytopenic, Idiopathic / Alzheimer Vaccines / Antibodies, Monoclonal, Humanized / Immunity, Heterologous Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans / Male Language: En Journal: MAbs Journal subject: ALERGIA E IMUNOLOGIA Year: 2021 Document type: Article Affiliation country: Country of publication: