Optimizing Subjective Cognitive Decline to Detect Early Cognitive Dysfunction.
J Alzheimers Dis
; 80(3): 1185-1196, 2021.
Article
in En
| MEDLINE
| ID: mdl-33646159
ABSTRACT
BACKGROUND:
The utility of subjective cognitive decline (SCD) as an indicator of preclinical AD is overshadowed by its inconsistent association with objective cognition.OBJECTIVE:
This study examines if manipulations of SCD measurement affect its association with early cognitive dysfunction characteristic of preclinical AD.METHODS:
Cognitively healthy older adults (nâ=â110) completed SCD questionnaires that elicited complaints in general, compared to 5 years ago (retrospective SCD) and compared to their peers (age-anchored SCD) in binary and Likert scales. Outcome cognitive tasks included an associative memory task (Face-Name Test), a visual short-term memory binding task (STMB test), and a clinical neuropsychological list learning test (Selective Reminder Test).RESULTS:
SCD complaints, when compared to age-matched peers (age-anchored SCD) were endorsed less frequently than complaints compared to 5 years ago (retrospective SCD) (pâ<â0.01). In demographically adjusted regressions, age-anchored ordinal-rated SCD was associated with short term memory binding (ß=â-0.22, pâ=â0.040, CIâ=â-0.45, -0.01), associative memory (ß=â-0.26, pâ=â0.018, CIâ=â-0.45, -0.06), and list learning (ß=â-0.31, pâ=â0.002, CIâ=â-0.51, -0.12). Retrospective and general ordinal-rated SCD was associated with associative memory (ß=â-0.25, pâ=â0.012, CIâ=â-0.44, -0.06; ß=â-0.29, pâ=â0.003, CIâ=â-0.47, -0.10) and list learning only (ß=â-0.25, pâ=â0.014, CIâ=â-0.45, -0.05; ß=â-0.28, pâ=â0.004, CIâ=â-0.48, -0.09).CONCLUSION:
Ordinal age-anchored SCD appears better suited than other SCD measurements to detect early cognitive dysfunction characteristic of preclinical AD.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Surveys and Questionnaires
/
Early Diagnosis
/
Diagnostic Self Evaluation
/
Cognitive Dysfunction
/
Neuropsychological Tests
Type of study:
Diagnostic_studies
/
Screening_studies
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Alzheimers Dis
Journal subject:
GERIATRIA
/
NEUROLOGIA
Year:
2021
Document type:
Article
Affiliation country: