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Rational affinity maturation of anti-amyloid antibodies with high conformational and sequence specificity.
Desai, Alec A; Smith, Matthew D; Zhang, Yulei; Makowski, Emily K; Gerson, Julia E; Ionescu, Edward; Starr, Charles G; Zupancic, Jennifer M; Moore, Shannon J; Sutter, Alexandra B; Ivanova, Magdalena I; Murphy, Geoffrey G; Paulson, Henry L; Tessier, Peter M.
Affiliation
  • Desai AA; Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan, USA.
  • Smith MD; Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan, USA.
  • Zhang Y; Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan, USA.
  • Makowski EK; Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan, USA; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan, USA.
  • Gerson JE; Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
  • Ionescu E; Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan, USA.
  • Starr CG; Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan, USA; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan, USA.
  • Zupancic JM; Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan, USA.
  • Moore SJ; Protein Folding Disease Initiative, University of Michigan, Ann Arbor, Michigan, USA; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA.
  • Sutter AB; Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA; Biophysics Program, University of Michigan, Ann Arbor, Michigan, USA.
  • Ivanova MI; Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA; Biophysics Program, University of Michigan, Ann Arbor, Michigan, USA.
  • Murphy GG; Protein Folding Disease Initiative, University of Michigan, Ann Arbor, Michigan, USA; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA.
  • Paulson HL; Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA; Protein Folding Disease Initiative, University of Michigan, Ann Arbor, Michigan, USA; Michigan Alzheimer's Disease Center, University of Michigan, Ann Arbor, Michigan, USA.
  • Tessier PM; Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan, USA; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, Michigan, USA; Protein Folding Disease Initiative, University of
J Biol Chem ; 296: 100508, 2021.
Article in En | MEDLINE | ID: mdl-33675750
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Amyloid / Antibodies, Monoclonal Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2021 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Amyloid / Antibodies, Monoclonal Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2021 Document type: Article Affiliation country: