Recent Advances in the Treatment of Opioid Use Disorder.
Curr Pain Headache Rep
; 25(4): 23, 2021 Mar 11.
Article
in En
| MEDLINE
| ID: mdl-33693999
ABSTRACT
PURPOSE OF REVIEW Opioid use disorder (OUD) remains a national epidemic with an immense consequence to the United States' healthcare system. Current therapeutic options are limited by adverse effects and limited efficacy. RECENT FINDINGS:
Recent advances in therapeutic options for OUD have shown promise in the fight against this ongoing health crisis. Modifications to approved medication-assisted treatment (MAT) include office-based methadone maintenance, implantable and monthly injectable buprenorphine, and an extended-release injectable naltrexone. Therapies under investigation include various strategies such as heroin vaccines, gene-targeted therapy, and biased agonism at the G protein-coupled receptor (GPCR), but several pharmacologic, clinical, and practical barriers limit these treatments' market viability. This manuscript provides a comprehensive review of the current literature regarding recent innovations in OUD treatment.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Analgesics, Opioid
/
Narcotic Antagonists
/
Opioid-Related Disorders
Limits:
Humans
Language:
En
Journal:
Curr Pain Headache Rep
Journal subject:
FISIOLOGIA
/
NEUROLOGIA
/
PSICOFISIOLOGIA
Year:
2021
Document type:
Article
Affiliation country: