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Safety and Immunogenicity of Adenovirus and Poxvirus Vectored Vaccines against a Mycobacterium Avium Complex Subspecies.
Folegatti, Pedro M; Flaxman, Amy; Jenkin, Daniel; Makinson, Rebecca; Kingham-Page, Lucy; Bellamy, Duncan; Ramos Lopez, Fernando; Sheridan, Jonathan; Poulton, Ian; Aboagye, Jeremy; Tran, Nguyen; Mitton, Celia; Roberts, Rachel; Lawrie, Alison M; Hill, Adrian V S; Ewer, Katie J; Gilbert, Sarah.
Affiliation
  • Folegatti PM; The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.
  • Flaxman A; The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.
  • Jenkin D; The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.
  • Makinson R; The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.
  • Kingham-Page L; The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.
  • Bellamy D; The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.
  • Ramos Lopez F; The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.
  • Sheridan J; The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.
  • Poulton I; The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.
  • Aboagye J; The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.
  • Tran N; The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.
  • Mitton C; The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.
  • Roberts R; The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.
  • Lawrie AM; The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.
  • Hill AVS; The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.
  • Ewer KJ; The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.
  • Gilbert S; The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.
Vaccines (Basel) ; 9(3)2021 Mar 16.
Article in En | MEDLINE | ID: mdl-33809415
ABSTRACT
Heterologous prime-boost strategies are known to substantially increase immune responses in viral vectored vaccines. Here we report on safety and immunogenicity of the poxvirus Modified Vaccinia Ankara (MVA) vectored vaccine expressing four Mycobacterium avium subspecies paratuberculosis antigens as a single dose or as a booster vaccine following a simian adenovirus (ChAdOx2) prime. We demonstrate that a heterologous prime-boost schedule is well tolerated and induced T-cell immune responses.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Vaccines (Basel) Year: 2021 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Vaccines (Basel) Year: 2021 Document type: Article Affiliation country: