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Discovery of novel potent migrastatic Thiazolo[5,4-b]pyridines targeting Lysyl-tRNA synthetase (KRS) for treatment of Cancer metastasis.
Lee, Seungbeom; Kwon, Nam Hoon; Seo, Bokyung; Lee, Jin Young; Cho, Hye Young; Kim, Kyeojin; Kim, Hyun Su; Jung, Kiwon; Jeon, Young Ho; Kim, Sunghoon; Suh, Young-Ger.
Affiliation
  • Lee S; College of Pharmacy, CHA University, Gyeonggi-do, 11160, Republic of Korea; College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
  • Kwon NH; Medicinal Bioconvergence Research Center, Institute for Artificial Intelligence and Biomedical Research, College of Pharmacy and College of Medicine, Gangnam Severance Hospital, Yonsei University, Incheon, South Korea, 21983.
  • Seo B; College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
  • Lee JY; College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
  • Cho HY; College of Pharmacy, Korea University, 2511 Sejong-ro, Sejong, 339-700, Republic of Korea.
  • Kim K; College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
  • Kim HS; College of Pharmacy, CHA University, Gyeonggi-do, 11160, Republic of Korea.
  • Jung K; College of Pharmacy, CHA University, Gyeonggi-do, 11160, Republic of Korea.
  • Jeon YH; College of Pharmacy, Korea University, 2511 Sejong-ro, Sejong, 339-700, Republic of Korea.
  • Kim S; Medicinal Bioconvergence Research Center, Institute for Artificial Intelligence and Biomedical Research, College of Pharmacy and College of Medicine, Gangnam Severance Hospital, Yonsei University, Incheon, South Korea, 21983. Electronic address: sunghoonkim@yonsei.ac.kr.
  • Suh YG; College of Pharmacy, CHA University, Gyeonggi-do, 11160, Republic of Korea; College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea. Electronic address: ygsuh@snu.ac.kr.
Eur J Med Chem ; 218: 113405, 2021 Jun 05.
Article in En | MEDLINE | ID: mdl-33831781
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Enzyme Inhibitors / Drug Discovery / Lysine-tRNA Ligase / Antineoplastic Agents Limits: Animals / Female / Humans Language: En Journal: Eur J Med Chem Year: 2021 Document type: Article Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Enzyme Inhibitors / Drug Discovery / Lysine-tRNA Ligase / Antineoplastic Agents Limits: Animals / Female / Humans Language: En Journal: Eur J Med Chem Year: 2021 Document type: Article Country of publication: