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Metformin leads to accumulation of reactive oxygen species by inhibiting the NFE2L1 expression in human hepatocellular carcinoma cells.
Gou, Shanshan; Qiu, Lu; Yang, Qiufang; Li, Peng; Zhou, Xiaowen; Sun, Yixuan; Zhou, Xiuman; Zhao, Wenshan; Zhai, Wenjie; Li, Guodong; Wu, Yahong; Ren, Yonggang; Qi, Yuanming; Zhang, Yiguo; Gao, Yanfeng.
Affiliation
  • Gou S; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China.
  • Qiu L; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China. Electronic address: qiulu@zzu.edu.cn.
  • Yang Q; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China.
  • Li P; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China.
  • Zhou X; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China.
  • Sun Y; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China.
  • Zhou X; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China.
  • Zhao W; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China.
  • Zhai W; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China.
  • Li G; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China.
  • Wu Y; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China.
  • Ren Y; Department of Biochemistry, North Sichuan Medical College, Nanchong 637000, China.
  • Qi Y; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China.
  • Zhang Y; The Laboratory of Cell Biochemistry and Topogenetic Regulation, College of Bioengineering and Faculty of Sciences, Chongqing University, Chongqing 400044, China.
  • Gao Y; School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China. Electronic address: gaoyf29@mail.sysu.edu.cn.
Toxicol Appl Pharmacol ; 420: 115523, 2021 06 01.
Article in En | MEDLINE | ID: mdl-33838154
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Reactive Oxygen Species / Carcinoma, Hepatocellular / Oxidative Stress / NF-E2-Related Factor 1 / Liver Neoplasms / Metformin / Antineoplastic Agents Limits: Humans Language: En Journal: Toxicol Appl Pharmacol Year: 2021 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Reactive Oxygen Species / Carcinoma, Hepatocellular / Oxidative Stress / NF-E2-Related Factor 1 / Liver Neoplasms / Metformin / Antineoplastic Agents Limits: Humans Language: En Journal: Toxicol Appl Pharmacol Year: 2021 Document type: Article Affiliation country: Country of publication: