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Microbiota-derived short chain fatty acids modulate microglia and promote Aß plaque deposition.
Colombo, Alessio Vittorio; Sadler, Rebecca Katie; Llovera, Gemma; Singh, Vikramjeet; Roth, Stefan; Heindl, Steffanie; Sebastian Monasor, Laura; Verhoeven, Aswin; Peters, Finn; Parhizkar, Samira; Kamp, Frits; Gomez de Aguero, Mercedes; MacPherson, Andrew J; Winkler, Edith; Herms, Jochen; Benakis, Corinne; Dichgans, Martin; Steiner, Harald; Giera, Martin; Haass, Christian; Tahirovic, Sabina; Liesz, Arthur.
Affiliation
  • Colombo AV; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
  • Sadler RK; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.
  • Llovera G; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.
  • Singh V; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.
  • Roth S; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.
  • Heindl S; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.
  • Sebastian Monasor L; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
  • Verhoeven A; Center for Proteomics and Metabolomics, Leiden University Medical Center (LUMC), Leiden, Netherlands.
  • Peters F; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
  • Parhizkar S; Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Kamp F; Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Gomez de Aguero M; Maurice Müller Laboratories (DKF), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, Bern, Switzerland.
  • MacPherson AJ; Maurice Müller Laboratories (DKF), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, Bern, Switzerland.
  • Winkler E; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
  • Herms J; Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Benakis C; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
  • Dichgans M; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
  • Steiner H; Center for Neuropathology and Prion Research, Ludwig-Maximilians University Munich, Munich, Germany.
  • Giera M; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.
  • Haass C; Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.
  • Tahirovic S; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
  • Liesz A; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
Elife ; 102021 04 13.
Article in En | MEDLINE | ID: mdl-33845942
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Microglia / Plaque, Amyloid / Fatty Acids, Volatile / Gastrointestinal Microbiome Limits: Animals Language: En Journal: Elife Year: 2021 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Microglia / Plaque, Amyloid / Fatty Acids, Volatile / Gastrointestinal Microbiome Limits: Animals Language: En Journal: Elife Year: 2021 Document type: Article Affiliation country: Country of publication: