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Advancements in Microfluidic Systems for the Study of Female Reproductive Biology.
Bodke, Vedant V; Burdette, Joanna E.
Affiliation
  • Bodke VV; Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago 60607, USA.
  • Burdette JE; Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago 60607, USA.
Endocrinology ; 162(10)2021 10 01.
Article in En | MEDLINE | ID: mdl-33852726
The female reproductive tract is a highly complex physiological system that consists of the ovaries, fallopian tubes, uterus, cervix, and vagina. An enhanced understanding of the molecular, cellular, and genetic mechanisms of the tract will allow for the development of more effective assisted reproductive technologies, therapeutics, and screening strategies for female specific disorders. Traditional 2-dimensional and 3-dimensional static culture systems may not always reflect the cellular and physical contexts or physicochemical microenvironment necessary to understand the dynamic exchange that is crucial for the functioning of the reproductive system. Microfluidic systems present a unique opportunity to study the female reproductive tract, as these systems recapitulate the multicellular architecture, contacts between different tissues, and microenvironmental cues that largely influence cell structure, function, behavior, and growth. This review discusses examples, challenges, and benefits of using microfluidic systems to model ovaries, fallopian tubes, endometrium, and placenta. Additionally, this review also briefly discusses the use of these systems in studying the effects of endocrine disrupting chemicals and diseases such as ovarian cancer, preeclampsia, and polycystic ovarian syndrome.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Microfluidics / Genitalia, Female Limits: Animals / Female / Humans / Pregnancy Language: En Journal: Endocrinology Year: 2021 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Microfluidics / Genitalia, Female Limits: Animals / Female / Humans / Pregnancy Language: En Journal: Endocrinology Year: 2021 Document type: Article Affiliation country: Country of publication: