Cell Lineage, Self-Renewal, and Epithelial-to-Mesenchymal Transition during Secondary Neurulation.
J Korean Neurosurg Soc
; 64(3): 367-373, 2021 May.
Article
in En
| MEDLINE
| ID: mdl-33906340
ABSTRACT
Secondary neurulation (SN) is a critical process to form the neural tube in the posterior region of the body including the tail. SN is distinct from the anteriorly occurring primary neurulation (PN); whereas the PN proceeds by folding an epithelial neural plate, SN precursors arise from a specified epiblast by epithelial-to-mesenchymal transition (EMT), and undergo self-renewal in the tail bud. They finally differentiate into the neural tube through mesenchymal-to-epithelial transition (MET). We here overview recent progresses in the studies of SN with a particular focus on the regulation of cell lineage, self-renewal, and EMT/MET. Cellular mechanisms underlying SN help to understand the functional diversity of the tail in vertebrates.
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Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
J Korean Neurosurg Soc
Year:
2021
Document type:
Article
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