Sphingolipids in HDL - Potential markers for adaptation to pregnancy?
Biochim Biophys Acta Mol Cell Biol Lipids
; 1866(8): 158955, 2021 08.
Article
in En
| MEDLINE
| ID: mdl-33933650
ABSTRACT
Plasma high density lipoprotein (HDL) exhibits many functions that render it an effective endothelial protective agent and may underlie its potential role in protecting the maternal vascular endothelium during pregnancy. In non-pregnant individuals, the HDL lipidome is altered in metabolic disease compared to healthy individuals and is linked to reduced cholesterol efflux, an effect that can be reversed by lifestyle management. Specific sphingolipids such as sphingosine-1-phosphate (S1P) have been shown to mediate the vaso-dilatory effects of plasma HDL via interaction with the endothelial nitric oxide synthase pathway. This review describes the relationship between plasma HDL and vascular function during healthy pregnancy and details how this is lost in pre-eclampsia, a disorder of pregnancy associated with widespread endothelial dysfunction. Evidence of a role for HDL sphingolipids, in particular S1P and ceramide, in cardiovascular disease and in healthy pregnancy and pre-eclampsia is discussed. Available data suggest that HDL-S1P and HDL-ceramide can mediate vascular protection in healthy pregnancy but not in preeclampsia. HDL sphingolipids thus are of potential importance in the healthy maternal adaptation to pregnancy.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sphingolipids
/
Adaptation, Physiological
/
Lipoproteins, HDL
Limits:
Female
/
Humans
/
Pregnancy
Language:
En
Journal:
Biochim Biophys Acta Mol Cell Biol Lipids
Year:
2021
Document type:
Article