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Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities.
Hayn, Manuel; Hirschenberger, Maximilian; Koepke, Lennart; Nchioua, Rayhane; Straub, Jan Hendrik; Klute, Susanne; Hunszinger, Victoria; Zech, Fabian; Prelli Bozzo, Caterina; Aftab, Wasim; Christensen, Maria Hønholt; Conzelmann, Carina; Müller, Janis Alexander; Srinivasachar Badarinarayan, Smitha; Stürzel, Christina Martina; Forne, Ignasi; Stenger, Steffen; Conzelmann, Karl-Klaus; Münch, Jan; Schmidt, Florian Ingo; Sauter, Daniel; Imhof, Axel; Kirchhoff, Frank; Sparrer, Konstantin Maria Johannes.
Affiliation
  • Hayn M; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
  • Hirschenberger M; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
  • Koepke L; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
  • Nchioua R; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
  • Straub JH; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
  • Klute S; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
  • Hunszinger V; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
  • Zech F; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
  • Prelli Bozzo C; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
  • Aftab W; Biomedical Center, Zentrallabor für Proteinanalytik (Protein Analysis Unit), Medical Faculty, Ludwig-Maximilians-Universität München, 82152 Planegg-Martinsried, Germany; Graduate School for Quantitative Biosciences (QBM), Ludwig-Maximilians-University of Munich, 81377 Munich, Germany.
  • Christensen MH; Institute of Innate Immunity, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
  • Conzelmann C; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
  • Müller JA; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
  • Srinivasachar Badarinarayan S; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany; Institute of Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, 72076 Tübingen, Germany.
  • Stürzel CM; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
  • Forne I; Biomedical Center, Zentrallabor für Proteinanalytik (Protein Analysis Unit), Medical Faculty, Ludwig-Maximilians-Universität München, 82152 Planegg-Martinsried, Germany.
  • Stenger S; Institute for Medical Microbiology and Hygiene, Ulm University Medical Center, 89081 Ulm, Germany.
  • Conzelmann KK; Max von Pettenkofer-Institute of Virology, Medical Faculty, and Gene Center, Ludwig-Maximilians-Universität München, 81377 Munich, Germany.
  • Münch J; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
  • Schmidt FI; Institute of Innate Immunity, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
  • Sauter D; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany; Institute of Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, 72076 Tübingen, Germany.
  • Imhof A; Biomedical Center, Zentrallabor für Proteinanalytik (Protein Analysis Unit), Medical Faculty, Ludwig-Maximilians-Universität München, 82152 Planegg-Martinsried, Germany.
  • Kirchhoff F; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
  • Sparrer KMJ; Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany. Electronic address: konstantin.sparrer@uni-ulm.de.
Cell Rep ; 35(7): 109126, 2021 05 18.
Article in En | MEDLINE | ID: mdl-33974846
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Viral Proteins / SARS-CoV-2 / COVID-19 Limits: Animals / Humans Language: En Journal: Cell Rep Year: 2021 Document type: Article Affiliation country:
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Viral Proteins / SARS-CoV-2 / COVID-19 Limits: Animals / Humans Language: En Journal: Cell Rep Year: 2021 Document type: Article Affiliation country: