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A cytokine receptor-masked IL2 prodrug selectively activates tumor-infiltrating lymphocytes for potent antitumor therapy.
Hsu, Eric J; Cao, Xuezhi; Moon, Benjamin; Bae, Joonbeom; Sun, Zhichen; Liu, Zhida; Fu, Yang-Xin.
Affiliation
  • Hsu EJ; Department of Immunology, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
  • Cao X; Department of Pathology, UT Southwestern Medical Center, Dallas, TX, 75390, USA. Xuezhi.Cao@UTSouthwestern.edu.
  • Moon B; Department of Immunology, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
  • Bae J; Department of Pathology, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
  • Sun Z; Department of Pathology, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
  • Liu Z; Department of Biomedical Engineering, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
  • Fu YX; Department of Pathology, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
Nat Commun ; 12(1): 2768, 2021 05 13.
Article in En | MEDLINE | ID: mdl-33986267
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Recombinant Fusion Proteins / Prodrugs / Interleukin-2 / CD8-Positive T-Lymphocytes / Neoplasms / Antineoplastic Agents Limits: Animals / Female / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2021 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Recombinant Fusion Proteins / Prodrugs / Interleukin-2 / CD8-Positive T-Lymphocytes / Neoplasms / Antineoplastic Agents Limits: Animals / Female / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2021 Document type: Article Affiliation country: Country of publication: