HIV-1 Envelope Conformation, Allostery, and Dynamics.
Viruses
; 13(5)2021 05 07.
Article
in En
| MEDLINE
| ID: mdl-34067073
ABSTRACT
The HIV-1 envelope glycoprotein (Env) mediates host cell fusion and is the primary target for HIV-1 vaccine design. The Env undergoes a series of functionally important conformational rearrangements upon engagement of its host cell receptor, CD4. As the sole target for broadly neutralizing antibodies, our understanding of these transitions plays a critical role in vaccine immunogen design. Here, we review available experimental data interrogating the HIV-1 Env conformation and detail computational efforts aimed at delineating the series of conformational changes connecting these rearrangements. These studies have provided a structural mapping of prefusion closed, open, and transition intermediate structures, the allosteric elements controlling rearrangements, and state-to-state transition dynamics. The combination of these investigations and innovations in molecular modeling set the stage for advanced studies examining rearrangements at greater spatial and temporal resolution.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
HIV Envelope Protein gp41
/
HIV-1
/
Env Gene Products, Human Immunodeficiency Virus
Language:
En
Journal:
Viruses
Year:
2021
Document type:
Article
Affiliation country: