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Seasonal fluctuations in serum levels of vitamin D in Japanese patients with multiple sclerosis.
Niino, Masaaki; Fukazawa, Toshiyuki; Miyazaki, Yusei; Ura, Shigeyuki; Takahashi, Eri; Minami, Naoya; Akimoto, Sachiko; Amino, Itaru; Naganuma, Ryoji; Kikuchi, Seiji.
Affiliation
  • Niino M; Department of Clinical Research, National Hospital Organization Hokkaido Medical Center, Sapporo, Japan. Electronic address: niino.masaaki.tc@mail.hosp.go.jp.
  • Fukazawa T; Sapporo Neurology Hospital, Sapporo, Japan.
  • Miyazaki Y; Department of Clinical Research, National Hospital Organization Hokkaido Medical Center, Sapporo, Japan.
  • Ura S; Department Neurology, Asahikawa Red Cross Hospital, Asahikawa, Japan.
  • Takahashi E; Department of Clinical Research, National Hospital Organization Hokkaido Medical Center, Sapporo, Japan.
  • Minami N; Department of Neurology, National Hospital Organization Hokkaido Medical Center, Sapporo, Japan.
  • Akimoto S; Department of Neurology, National Hospital Organization Hokkaido Medical Center, Sapporo, Japan.
  • Amino I; Department of Neurology, National Hospital Organization Hokkaido Medical Center, Sapporo, Japan.
  • Naganuma R; Department of Neurology, National Hospital Organization Hokkaido Medical Center, Sapporo, Japan.
  • Kikuchi S; Department of Neurology, National Hospital Organization Hokkaido Medical Center, Sapporo, Japan.
J Neuroimmunol ; 357: 577624, 2021 08 15.
Article in En | MEDLINE | ID: mdl-34098399
ABSTRACT
We explored the presence of seasonal fluctuations in serum vitamin D levels and potential relationship between vitamin D levels and disease severity or prognosis in patients with multiple sclerosis (MS) in northern Japan. Serum levels of 25(OH)D in spring were significantly lower than in summer and autumn, whereas no differences in 1,25(OH)2D levels were demonstrated among four seasons. Seasonal fluctuations in 25(OH)D were demonstrated in patients with EDSS ≤3.5, but not in those with EDSS≥4.0. Negative correlations between 25(OH)D and EDSS or MSSS were found in each season. Seasonal fluctuations in 25(OH)D levels may be affected by physical disabilities.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Seasons / Vitamin D / Multiple Sclerosis Type of study: Observational_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: J Neuroimmunol Year: 2021 Document type: Article
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Seasons / Vitamin D / Multiple Sclerosis Type of study: Observational_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: J Neuroimmunol Year: 2021 Document type: Article