Seasonal fluctuations in serum levels of vitamin D in Japanese patients with multiple sclerosis.
J Neuroimmunol
; 357: 577624, 2021 08 15.
Article
in En
| MEDLINE
| ID: mdl-34098399
ABSTRACT
We explored the presence of seasonal fluctuations in serum vitamin D levels and potential relationship between vitamin D levels and disease severity or prognosis in patients with multiple sclerosis (MS) in northern Japan. Serum levels of 25(OH)D in spring were significantly lower than in summer and autumn, whereas no differences in 1,25(OH)2D levels were demonstrated among four seasons. Seasonal fluctuations in 25(OH)D were demonstrated in patients with EDSS ≤3.5, but not in those with EDSS≥4.0. Negative correlations between 25(OH)D and EDSS or MSSS were found in each season. Seasonal fluctuations in 25(OH)D levels may be affected by physical disabilities.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Seasons
/
Vitamin D
/
Multiple Sclerosis
Type of study:
Observational_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
J Neuroimmunol
Year:
2021
Document type:
Article