Identifying Mitochondrial-Related Genes NDUFA10 and NDUFV2 as Prognostic Markers for Prostate Cancer through Biclustering.
Biomed Res Int
; 2021: 5512624, 2021.
Article
in En
| MEDLINE
| ID: mdl-34124242
ABSTRACT
Prostate cancer is currently associated with higher morbidity and mortality in men in the United States and Western Europe, so it is important to identify genes that regulate prostate cancer. The high-dimension gene expression profile impedes the discovery of biclusters which are of great significance to the identification of the basic cellular processes controlled by multiple genes and the identification of large-scale unknown effects hidden in the data. We applied the biclustering method MCbiclust to explore large biclusters in the TCGA cohort through a large number of iterations. Two biclusters were found with the highest silhouette coefficient value. The expression patterns of one bicluster are highly similar to those found by the gene expression profile of the known androgen-regulated genes. Further gene set enrichment revealed that mitochondrial function-related genes were negatively correlated with AR regulation-related genes. Then, we performed differential analysis, AR binding site analysis, and survival analysis on the core genes with high phenotypic contribution. Among the core genes, NDUFA10 showed a low expression value in cancer patients across different expression profiles, while NDUFV2 showed a high expression value in cancer patients. Survival analysis of NDUFA10 and NDUFV2 demonstrated that both genes were unfavorable prognostic markers.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prostatic Neoplasms
/
Biomarkers, Tumor
/
Gene Expression Regulation, Enzymologic
/
Gene Expression Regulation, Neoplastic
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Mitochondrial Proteins
/
Databases, Nucleic Acid
/
NADH Dehydrogenase
/
Neoplasm Proteins
Type of study:
Prognostic_studies
Limits:
Humans
/
Male
Language:
En
Journal:
Biomed Res Int
Year:
2021
Document type:
Article
Affiliation country: