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SARS-CoV-2 Seropositivity and Seroconversion in Patients Undergoing Active Cancer-Directed Therapy.
Sun, Lova; Surya, Sanjna; Goodman, Noah G; Le, Anh N; Kelly, Gregory; Owoyemi, Olutosin; Desai, Heena; Zheng, Cathy; DeLuca, Shannon; Good, Madeline L; Hussain, Jasmin; Jeffries, Seth D; Kry, Yolanda R; Kugler, Emily M; Mansour, Maikel; Ndicu, John; Osei-Akoto, AnnaClaire; Prior, Timothy; Pundock, Stacy L; Varughese, Lisa A; Weaver, JoEllen; Doucette, Abigail; Dudek, Scott; Verma, Shefali Setia; Gouma, Sigrid; Weirick, Madison E; McAllister, Christopher M; Bange, Erin; Gabriel, Peter; Ritchie, Marylyn; Rader, Daniel J; Vonderheide, Robert H; Schuchter, Lynn M; Verma, Anurag; Maillard, Ivan; Mamtani, Ronac; Hensley, Scott E; Gross, Robert; Wileyto, E Paul; Huang, Alexander C; Maxwell, Kara N; DeMichele, Angela.
Affiliation
  • Sun L; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • Surya S; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • Goodman NG; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • Le AN; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • Kelly G; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • Owoyemi O; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • Desai H; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • Zheng C; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • DeLuca S; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • Good ML; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • Hussain J; Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • Jeffries SD; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • Kry YR; Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • Kugler EM; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • Mansour M; Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • Ndicu J; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • Osei-Akoto A; Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • Prior T; Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • Pundock SL; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • Varughese LA; Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • Weaver J; Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • Doucette A; Department of Radiation Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • Dudek S; Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • Verma SS; Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • Gouma S; Department of Microbiology, University of Pennsylvania, Philadelphia, PA.
  • Weirick ME; Department of Microbiology, University of Pennsylvania, Philadelphia, PA.
  • McAllister CM; Department of Microbiology, University of Pennsylvania, Philadelphia, PA.
  • Bange E; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • Gabriel P; Department of Radiation Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • Ritchie M; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA.
  • Rader DJ; Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • Vonderheide RH; Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • Schuchter LM; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • Verma A; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA.
  • Maillard I; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • Mamtani R; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA.
  • Hensley SE; Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • Gross R; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • Wileyto EP; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA.
  • Huang AC; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
  • Maxwell KN; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA.
  • DeMichele A; Department of Microbiology, University of Pennsylvania, Philadelphia, PA.
JCO Oncol Pract ; 17(12): e1879-e1886, 2021 12.
Article in En | MEDLINE | ID: mdl-34133219
ABSTRACT

PURPOSE:

Multiple studies have demonstrated the negative impact of cancer care delays during the COVID-19 pandemic, and transmission mitigation techniques are imperative for continued cancer care delivery. We aimed to gauge the effectiveness of these measures at the University of Pennsylvania.

METHODS:

We conducted a longitudinal study of SARS-CoV-2 antibody seropositivity and seroconversion in patients presenting to infusion centers for cancer-directed therapy between May 21, 2020, and October 8, 2020. Participants completed questionnaires and had up to five serial blood collections.

RESULTS:

Of 124 enrolled patients, only two (1.6%) had detectable SARS-CoV-2 antibodies on initial blood draw, and no initially seronegative patients developed newly detectable antibodies on subsequent blood draw(s), corresponding to a seroconversion rate of 0% (95% CI, 0.0 TO 4.1%) over 14.8 person-years of follow up, with a median of 13 health care visits per patient.

CONCLUSION:

These results suggest that patients with cancer receiving in-person care at a facility with aggressive mitigation efforts have an extremely low likelihood of COVID-19 infection.
Subject(s)
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: COVID-19 / Neoplasms Type of study: Observational_studies Limits: Humans Language: En Journal: JCO Oncol Pract Year: 2021 Document type: Article Affiliation country:
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: COVID-19 / Neoplasms Type of study: Observational_studies Limits: Humans Language: En Journal: JCO Oncol Pract Year: 2021 Document type: Article Affiliation country: