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Herpesviruses and the hidden links to Multiple Sclerosis neuropathology.
Jakhmola, Shweta; Upadhyay, Arun; Jain, Khushboo; Mishra, Amit; Jha, Hem Chandra.
Affiliation
  • Jakhmola S; Infection Bioengineering Group, Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, India.
  • Upadhyay A; Cellular and Molecular Neurobiology Unit, Indian Institute of Technology, Jodhpur, India.
  • Jain K; Infection Bioengineering Group, Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, India.
  • Mishra A; Cellular and Molecular Neurobiology Unit, Indian Institute of Technology, Jodhpur, India.
  • Jha HC; Infection Bioengineering Group, Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, India. Electronic address: hemcjha@iiti.ac.in.
J Neuroimmunol ; 358: 577636, 2021 09 15.
Article in En | MEDLINE | ID: mdl-34174587
ABSTRACT
Herpesviruses like Epstein-Barr virus, human herpesvirus (HHV)-6, HHV-1, VZV, and human endogenous retroviruses, have an age-old clinical association with multiple sclerosis (MS). MS is an autoimmune disease of the nervous system wherein the myelin sheath deteriorates. The most popular mode of virus mediated immune system manipulation is molecular mimicry. Numerous herpesvirus antigens are similar to myelin proteins. Other mechanisms described here include the activity of cytokines and autoantibodies produced by the autoreactive T and B cells, respectively, viral déjà vu, epitope spreading, CD46 receptor engagement, impaired remyelination etc. Overall, this review addresses the host-parasite association of viruses with MS.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoantibodies / Herpesviridae / Multiple Sclerosis Limits: Humans Language: En Journal: J Neuroimmunol Year: 2021 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoantibodies / Herpesviridae / Multiple Sclerosis Limits: Humans Language: En Journal: J Neuroimmunol Year: 2021 Document type: Article Affiliation country: