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Folate receptor α increases chemotherapy resistance through stabilizing MDM2 in cooperation with PHB2 that is overcome by MORAb-202 in gastric cancer.
Sakai, Hitomi; Kawakami, Hisato; Teramura, Takeshi; Onodera, Yuta; Somers, Elizabeth; Furuuchi, Keiji; Uenaka, Toshimitsu; Kato, Ryoji; Nakagawa, Kazuhiko.
Affiliation
  • Sakai H; Department of Medical Oncology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan.
  • Kawakami H; Department of Medical Oncology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan.
  • Teramura T; Division of Cell Biology for Regenerative Medicine, Institute of Advanced Clinical Medicine, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan.
  • Onodera Y; Division of Cell Biology for Regenerative Medicine, Institute of Advanced Clinical Medicine, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan.
  • Somers E; AD Franchise Special Mission, Eisai Inc., Woodcliff Lake, New Jersey, USA.
  • Furuuchi K; Epochal Precision Anti-Cancer Therapeutics (EPAT), Eisai Inc., Exton, Pennsylvania, USA.
  • Uenaka T; Epochal Precision Anti-Cancer Therapeutics (EPAT), Eisai Inc., Exton, Pennsylvania, USA.
  • Kato R; Department of Medical Oncology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan.
  • Nakagawa K; Department of Medical Oncology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan.
Clin Transl Med ; 11(6): e454, 2021 06.
Article in En | MEDLINE | ID: mdl-34185411
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stomach Neoplasms / Gene Expression Regulation, Neoplastic / Drug Resistance, Neoplasm / Proto-Oncogene Proteins c-mdm2 / Folate Receptor 1 / Antibodies, Monoclonal, Humanized / Furans / Prohibitins / Ketones Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Clin Transl Med Year: 2021 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stomach Neoplasms / Gene Expression Regulation, Neoplastic / Drug Resistance, Neoplasm / Proto-Oncogene Proteins c-mdm2 / Folate Receptor 1 / Antibodies, Monoclonal, Humanized / Furans / Prohibitins / Ketones Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Clin Transl Med Year: 2021 Document type: Article Affiliation country: