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COVID-19 autopsy cases: detection of virus in endocrine tissues.
Poma, A M; Bonuccelli, D; Giannini, R; Macerola, E; Vignali, P; Ugolini, C; Torregrossa, L; Proietti, A; Pistello, M; Basolo, A; Santini, F; Toniolo, A; Basolo, F.
Affiliation
  • Poma AM; Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Via Savi,10, 56126, Pisa, Italy.
  • Bonuccelli D; Department of Forensic Medicine, Azienda USL Toscana Nordovest, Lucca, Italy.
  • Giannini R; Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Via Savi,10, 56126, Pisa, Italy.
  • Macerola E; Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Via Savi,10, 56126, Pisa, Italy.
  • Vignali P; Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Via Savi,10, 56126, Pisa, Italy.
  • Ugolini C; Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Via Savi,10, 56126, Pisa, Italy.
  • Torregrossa L; Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Via Savi,10, 56126, Pisa, Italy.
  • Proietti A; Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Via Savi,10, 56126, Pisa, Italy.
  • Pistello M; Retrovirus Center and Virology Section, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
  • Basolo A; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
  • Santini F; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
  • Toniolo A; Global Virus Network, University of Insubria, Varese, Italy.
  • Basolo F; Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Via Savi,10, 56126, Pisa, Italy. fulvio.basolo@med.unipi.it.
J Endocrinol Invest ; 45(1): 209-214, 2022 Jan.
Article in En | MEDLINE | ID: mdl-34191258
PURPOSE: The SARS-CoV-2 genome has been detected in a variety of human samples including blood, urine, semen, and faeces. However, evidence of virus presence in tissues other than lung are limited. METHODS: We investigated whether SARS-CoV-2 could be detected in 50 autoptic specimens of endocrine organs from 29 patients who died of COVID-19. RESULTS: The virus was detected in 25 specimens including ten abdominal subcutaneous adipose tissue samples (62%), six testes (67%), and nine thyroid (36%) samples. The analysis of multiple endocrine organ samples obtained from the same patients showed that, in virus-positive cases, the viral genome was consistently detected in all but two matched specimens. CONCLUSION: Our findings show that the virus spread into endocrine organs is a common event in severe cases. Further studies should assess the rate of the phenomenon in clinically mild cases. The potential long-term effects of COVID-19 on endocrine functions should be taken into consideration.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Endocrine Glands / SARS-CoV-2 / COVID-19 Type of study: Diagnostic_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: J Endocrinol Invest Year: 2022 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Endocrine Glands / SARS-CoV-2 / COVID-19 Type of study: Diagnostic_studies Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: J Endocrinol Invest Year: 2022 Document type: Article Affiliation country: Country of publication: