Framing Effects on Decision-Making for Diagnostic Genetic Testing: Results from a Randomized Trial.
Genes (Basel)
; 12(6)2021 06 20.
Article
in En
| MEDLINE
| ID: mdl-34202935
Genetic testing is increasingly part of routine clinical care. However, testing decisions may be characterized by regret as findings also implicate blood relatives. It is not known if genetic testing decisions are affected by the way information is presented (i.e., framing effects). We employed a randomized factorial design to examine framing effects on hypothetical genetic testing scenarios (common, life-threatening disease and rare, life-altering disease). Participants (n = 1012) received one of six decision frames: choice, default (n = 2; opt-in, opt-out), or enhanced choice (n = 3, based on the Theory of Planned Behavior). We compared testing decision, satisfaction, regret, and decision cognitions across decision frames and between scenarios. Participants randomized to 'choice' were least likely to opt for genetic testing compared with default and enhanced choice frames (78% vs. 83-91%, p < 0.05). Neither satisfaction nor regret differed across frames. Perceived autonomy (behavioral control) predicted satisfaction (B = 0.085, p < 0.001) while lack of control predicted regret (B = 0.346, p < 0.001). Opting for genetic testing did not differ between disease scenarios (p = 0.23). Results suggest framing can nudge individuals towards opting for genetic testing. These findings have important implications for individual self-determination in the genomic era. Similarities between scenarios with disparate disease trajectories point to possible modular approaches for web-based decisional support.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Choice Behavior
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Genetic Testing
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Patient Preference
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Hereditary Breast and Ovarian Cancer Syndrome
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Genetic Counseling
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Hypogonadism
Type of study:
Clinical_trials
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Diagnostic_studies
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Prognostic_studies
Aspects:
Patient_preference
Limits:
Adult
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Female
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Humans
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Male
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Middle aged
Language:
En
Journal:
Genes (Basel)
Year:
2021
Document type:
Article
Affiliation country:
Country of publication: