Biomaterials and osteoradionecrosis of the jaw: Review of the literature according to the SWiM methodology.
Eur Ann Otorhinolaryngol Head Neck Dis
; 139(4): 208-215, 2022 Aug.
Article
in En
| MEDLINE
| ID: mdl-34210630
ABSTRACT
OBJECTIVES:
To systematically present and interpret the current literature on research and treatment perspectives for mandibular osteoradionecrosis (mORN) in the field of biomaterials. MATERIAL ANDMETHODS:
A systematic review of the literature using the "Synthesis without meta-analysis" (SWiM) methodology was performed on PubMed, Embase and Cochrane, focusing on the implantation of synthetic biomaterials for bone reconstruction in mORN in humans and/or animal models. The primary endpoints were the composition, efficacy on mORN and tolerance of the implanted synthetic biomaterials.RESULTS:
Forty-seven references were obtained and evaluated in full-text by two assessors. Ten (8 in humans and 2 in animal models) met the eligibility criteria and were included for analysis. Materials most often comprised support plates or metal mesh (5 of 10 cases) in combination with grafts or synthetic materials (phosphocalcic ceramics, glutaraldehyde). Other ceramic/polymer composites were also implanted. In half of the selected reports, active compounds (molecules, growth factors, lysates) and/or cells were associated with the reconstruction material. The number of articles referring to implantation of biomaterials for the treatment of mORN was small, and the properties of the implanted biomaterials were generally poorly described, thus limiting a thorough understanding of their role.CONCLUSION:
In preventing the morbidity associated with some reconstructive surgeries, basic research has benefitted from recent advances in tissue engineering and biomaterials to repair limited bone loss.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Osteoradionecrosis
/
Plastic Surgery Procedures
Type of study:
Prognostic_studies
/
Systematic_reviews
Limits:
Animals
/
Humans
Language:
En
Journal:
Eur Ann Otorhinolaryngol Head Neck Dis
Year:
2022
Document type:
Article
Affiliation country: