A mimotope attached to an ITIM-SHP-1 interaction inhibitory peptide boosts immune response and efficacy.
RSC Med Chem
; 12(6): 994-999, 2021 Jun 23.
Article
in En
| MEDLINE
| ID: mdl-34223164
ABSTRACT
Antigen binding to the B-cell receptor initiates a downstream signalling pathway that contains both stimulatory and damping components. A malarial parasite-derived conformation-constrained peptide was conjugated to a signal-damping pathway inhibitor. Mice immunized with this antigen produced higher antibody levels which delayed parasitemia. This represents a new approach to antigen design.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
RSC Med Chem
Year:
2021
Document type:
Article