A mimotope attached to an ITIM-SHP-1 interaction inhibitory peptide boosts immune response and efficacy.

Roy, Koushik; Roy, Syamal; Roy, Siddhartha

Roy, Koushik; Roy, Syamal; Roy, Siddhartha.

Affiliation

Roy K; Division of Structural Biology and Bioinformatics, CSIR-Indian Institute of Chemical Biology 4, Raja S.C.Mullick Road Kolkata 700032 India.
Roy S; Infectious Diseases and Immunology Division, CSIR-Indian Institute of Chemical Biology 4, Raja S.C. Mullick Road Kolkata 700032 India.
Roy S; Department of Biophysics, Bose Institute P1/12, CIT Scheme VII M Kolkata 700054 India sidroykolkata@gmail.com.

RSC Med Chem ; 12(6): 994-999, 2021 Jun 23.

Article in En | MEDLINE | ID: mdl-34223164

ABSTRACT

ABSTRACT

Antigen binding to the B-cell receptor initiates a downstream signalling pathway that contains both stimulatory and damping components. A malarial parasite-derived conformation-constrained peptide was conjugated to a signal-damping pathway inhibitor. Mice immunized with this antigen produced higher antibody levels which delayed parasitemia. This represents a new approach to antigen design.

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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: RSC Med Chem Year: 2021 Document type: Article

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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: RSC Med Chem Year: 2021 Document type: Article