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Developments in Biological Mechanisms and Treatments for Negative Symptoms and Cognitive Dysfunction of Schizophrenia.
Wu, Qiongqiong; Wang, Xiaoyi; Wang, Ying; Long, Yu-Jun; Zhao, Jing-Ping; Wu, Ren-Rong.
Affiliation
  • Wu Q; National Clinical Research Center for Mental Disorders, Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, 410011, China.
  • Wang X; National Clinical Research Center for Mental Disorders, Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, 410011, China.
  • Wang Y; National Clinical Research Center for Mental Disorders, Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, 410011, China.
  • Long YJ; National Clinical Research Center for Mental Disorders, Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, 410011, China.
  • Zhao JP; National Clinical Research Center for Mental Disorders, Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, 410011, China. zhaojingping@csu.edu.cn.
  • Wu RR; National Clinical Research Center for Mental Disorders, Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, 410011, China. wurenrong@csu.edu.cn.
Neurosci Bull ; 37(11): 1609-1624, 2021 Nov.
Article in En | MEDLINE | ID: mdl-34227057
ABSTRACT
The causal mechanisms and treatment for the negative symptoms and cognitive dysfunction in schizophrenia are the main issues attracting the attention of psychiatrists over the last decade. The first part of this review summarizes the pathogenesis of schizophrenia, especially the negative symptoms and cognitive dysfunction from the perspectives of genetics and epigenetics. The second part describes the novel medications and several advanced physical therapies (e.g., transcranial magnetic stimulation and transcranial direct current stimulation) for the negative symptoms and cognitive dysfunction that will optimize the therapeutic strategy for patients with schizophrenia in future.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Schizophrenia / Cognitive Dysfunction / Transcranial Direct Current Stimulation Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Neurosci Bull Journal subject: NEUROLOGIA Year: 2021 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Schizophrenia / Cognitive Dysfunction / Transcranial Direct Current Stimulation Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Neurosci Bull Journal subject: NEUROLOGIA Year: 2021 Document type: Article Affiliation country: