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Clear Cell Carcinoma in the Oral Cavity with Three Novel Types of EWSR1-ATF1 Translocation: A Case Report.
Nojima, Satoshi; Kohara, Masaharu; Harada, Hiroshi; Kajikawa, Hitomi; Hirose, Katsutoshi; Nakatsuka, Shin-Ichi; Nakagawa, Yukinobu; Oya, Kaori; Fukuda, Yasuo; Matsunaga, Kazuhide; Uzawa, Narikazu; Fujimoto, Manabu; Toyosawa, Satoru; Morii, Eiichi.
Affiliation
  • Nojima S; Department of Pathology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Kohara M; Department of Pathology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Harada H; Department of Diagnostic Pathology and Cytology, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka, 541-8567, Japan.
  • Kajikawa H; Department of Oral and Maxillofacial Surgery II, Osaka University Graduate School of Dentistry, Suita, Osaka, 565-0871, Japan.
  • Hirose K; Department of Oral Pathology, Graduate School of Dentistry, Osaka University, 1-8 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Nakatsuka SI; Department of Diagnostic Pathology and Cytology, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka, 541-8567, Japan.
  • Nakagawa Y; Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, 565-0871, Japan.
  • Oya K; Clinical Laboratory, Osaka University Dental Hospital, 1-8 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Fukuda Y; Clinical Laboratory, Osaka University Dental Hospital, 1-8 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Matsunaga K; Department of Oral and Maxillofacial Surgery II, Osaka University Graduate School of Dentistry, Suita, Osaka, 565-0871, Japan.
  • Uzawa N; Department of Oral and Maxillofacial Surgery II, Osaka University Graduate School of Dentistry, Suita, Osaka, 565-0871, Japan.
  • Fujimoto M; Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, 565-0871, Japan.
  • Toyosawa S; Department of Oral Pathology, Graduate School of Dentistry, Osaka University, 1-8 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Morii E; Department of Pathology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. morii@molpath.med.osaka-u.ac.jp.
Head Neck Pathol ; 16(2): 560-566, 2022 Jun.
Article in En | MEDLINE | ID: mdl-34251595
ABSTRACT
Clear cell carcinoma (CCC) is a rare epithelial malignant tumor of the salivary glands. It is characterized by tumor cells with clear cytoplasm, hyalinized stroma, and most importantly the fusion genes EWSR1-ATF1, EWSR1-CREM, and EWSR1-PLAG1. Break-apart FISH has been performed for multiple CCC cases, but direct sequencing analysis has been performed in relatively few. Herein, we report an interesting case of CCC harboring three EWSR1-ATF1 translocations EWSR1 exon 8-ATF1 exon 4, EWSR1 exon 7-ATF1 exon 4, and EWSR1 exon 7-ATF1 exon 5. This case indicates the possibility of independent EWSR1-ATF1 gene translocations, and could provide insight into CCC tumorgenesis.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oncogene Proteins, Fusion / Adenocarcinoma, Clear Cell Limits: Humans Language: En Journal: Head Neck Pathol Journal subject: NEOPLASIAS / PATOLOGIA Year: 2022 Document type: Article Affiliation country:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oncogene Proteins, Fusion / Adenocarcinoma, Clear Cell Limits: Humans Language: En Journal: Head Neck Pathol Journal subject: NEOPLASIAS / PATOLOGIA Year: 2022 Document type: Article Affiliation country: