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Evaluation of peripherin in biofluids of patients with motor neuron diseases.
Sabbatini, Daniele; Raggi, Flavia; Ruggero, Susanna; Seguso, Mara; Mandrioli, Jessica; Cagnin, Annachiara; Briani, Chiara; Toffanin, Elisabetta; Gizzi, Matteo; Fortuna, Andrea; Bello, Luca; Pegoraro, Elena; Musso, Giulia; Sorarù, Gianni.
Affiliation
  • Sabbatini D; Department of Neurosciences, University of Padova, Padova, Italy.
  • Raggi F; Department of Neurosciences, University of Padova, Padova, Italy.
  • Ruggero S; Department of Neurosciences, General Hospital of Padua, Padova, Italy.
  • Seguso M; Department of Neurosciences, University of Padova, Padova, Italy.
  • Mandrioli J; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, 41125, Italy.
  • Cagnin A; Department of Neurosciences, Azienda Ospedaliera Universitaria Modena, Modena, 41126, Italy.
  • Briani C; Department of Neurosciences, University of Padova, Padova, Italy.
  • Toffanin E; Department of Neurosciences, University of Padova, Padova, Italy.
  • Gizzi M; Department of Neurosciences, General Hospital of Padua, Padova, Italy.
  • Fortuna A; Department of Neurosciences, University of Padova, Padova, Italy.
  • Bello L; Department of Neurosciences, University of Padova, Padova, Italy.
  • Pegoraro E; Department of Neurosciences, University of Padova, Padova, Italy.
  • Musso G; Department of Neurosciences, University of Padova, Padova, Italy.
  • Sorarù G; Department of Laboratory Medicine, University of Padova, Padova, Italy.
Ann Clin Transl Neurol ; 8(8): 1750-1754, 2021 08.
Article in En | MEDLINE | ID: mdl-34264016
ABSTRACT
Peripherin (PRPH), a type III intermediate filament, assembles with neurofilaments in neurons of the peripheral nervous system, including lower motor neurons (LMN). To evaluate the role of PRPH in LMN degeneration, we assessed PRPH and neurofilament light chain (NfL) in cerebrospinal fluid (CSF) and serum of 91 patients with motor neuron diseases (MND) and 69 controls. Overall, we found PRPH to be more concentrated in serum than in CSF. Serum PRPH resulted significantly increased in MND patients but it was unrelated to CSF-NfL or survival in the amyotrophic lateral sclerosis (ALS) subset. PRPH might represent a marker of LMN involvement.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neurofilament Proteins / Motor Neuron Disease / Peripherins Type of study: Observational_studies Limits: Humans Language: En Journal: Ann Clin Transl Neurol Year: 2021 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neurofilament Proteins / Motor Neuron Disease / Peripherins Type of study: Observational_studies Limits: Humans Language: En Journal: Ann Clin Transl Neurol Year: 2021 Document type: Article Affiliation country: