Reduced cognitive ability in people with rheumatoid arthritis compared with age-matched healthy controls.
Rheumatol Adv Pract
; 5(2): rkab044, 2021.
Article
in En
| MEDLINE
| ID: mdl-34350373
ABSTRACT
OBJECTIVE:
The aim was to compare the cognitive ability of people with RA with healthy controls (HCs).METHODS:
People with RA were recruited from the Norfolk Arthritis Register (NOAR), a population-based cohort study of people with inflammatory arthritis. Data on aged-matched HCs (people with no cognitive impairment) came from the comparison arm of The Dementia Research and Care Clinic Study (TRACC). People with RA and HCs performed a range of cognitive ability tasks to assess attention, memory, verbal fluency, language, visuospatial skills, emotional recognition, executive function and theory of mind. A score of <88 on the Addenbrooke's Cognitive Examination III was considered cognitive impairment. Scores were compared using linear regression adjusting for age, sex, smoking status, education, BMI, anxiety and depression.RESULTS:
Thirty-eight people with RA [mean (S.D.) age 69.1 (8.0) years; 25 (65.8%) women] were matched with 28 HCs [mean (S.D.) age 68.2 (6.4) years; 15 (53.6%) women]. Twenty-three (60.5%) people with RA were considered to have mild cognitive impairment [mean (S.D.) Addenbrooke's Cognitive Examination III RA = 85.2 (7.4), HC = 96.0 (2.5)]. People with RA had impairments in memory, verbal fluency, visuospatial functioning, executive function and emotional recognition in faces compared with HCs, after adjustment for confounders.CONCLUSION:
People with RA had cognitive impairments in a range of domains. People with RA might benefit from cognitive impairment screening to allow for early administration of appropriate interventions.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Observational_studies
Language:
En
Journal:
Rheumatol Adv Pract
Year:
2021
Document type:
Article